GLRA3

GLRA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CFB
Identifiers
Aliases	GLRA3, glycine receptor alpha 3
External IDs	OMIM: 600421; MGI: 95749; HomoloGene: 142; GeneCards: GLRA3; OMA:GLRA3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	174,829,247 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	56,583,105 bp
RNA expression pattern
	Top expressed in
	testicle; ; pancreatic ductal cell; ; prefrontal cortex; ; islet of Langerhans; ; gonad; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; hypothalamus;
	Top expressed in
	substantia nigra; ; ventromedial nucleus; ; ventral tegmental area; ; anterior amygdaloid area; ; dorsomedial hypothalamic nucleus; ; superior colliculus; ; paraventricular nucleus of hypothalamus; ; lumbar subsegment of spinal cord; ; lateral hypothalamus; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	glycine-gated chloride ion channel activity; glycine binding; metal ion binding; transmitter-gated ion channel activity; chloride channel activity; extracellular ligand-gated ion channel activity; extracellularly glycine-gated chloride channel activity; ion channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; cell projection; membrane; plasma membrane; synapse; integral component of plasma membrane; chloride channel complex; glycine-gated chloride channel complex; cell junction; dendrite; neuron projection;
Biological process	response to amino acid; chloride transmembrane transport; ion transport; synaptic transmission, glycinergic; chloride transport; neuropeptide signaling pathway; protein homooligomerization; excitatory postsynaptic potential; ion transmembrane transport; signal transduction; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	8001
	110304
	ENSG00000145451
	ENSMUSG00000038257
	O75311
	Q91XP5
	NM_001042543; NM_006529
	NM_080438; NM_001368774
	NP_001036008; NP_006520
	NP_536686; NP_001355703
	Wikidata
View/Edit Human	View/Edit Mouse

The Glycine receptor subunit alpha-3 is a protein that in humans is encoded by the GLRA3 gene.^[5] The protein encoded by this gene is a subunit of the glycine receptor.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145451 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038257 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Nikolic Z, Laube B, Weber RG, Lichter P, Kioschis P, Poustka A, Mulhardt C, Becker CM (Sep 1998). "The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts". J Biol Chem. 273 (31): 19708–14. doi:10.1074/jbc.273.31.19708. PMID 9677400.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145451 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038257 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9677400-5] Nikolic Z, Laube B, Weber RG, Lichter P, Kioschis P, Poustka A, Mulhardt C, Becker CM (Sep 1998). "The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts". J Biol Chem. 273 (31): 19708–14. doi:10.1074/jbc.273.31.19708. PMID 9677400.

[1]

[2]

[3]

[4]

[5]