GM2A

GM2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G13, 1PU5, 1PUB, 1TJJ, 2AF9, 2AG2, 2AG4, 2AG9
Identifiers
Aliases	GM2A, GM2-AP, SAP-3, GM2 ganglioside activator, GM2AP, ganglioside GM2 activator
External IDs	OMIM: 613109; MGI: 95762; HomoloGene: 349; GeneCards: GM2A; OMA:GM2A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,270,440 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	55,003,855 bp
RNA expression pattern
	Top expressed in
	vulva; ; human penis; ; placenta; ; cervix epithelium; ; gums; ; gingival epithelium; ; skin of thigh; ; nipple; ; skin of hip; ; inferior ganglion of vagus nerve;
	Top expressed in
	gastrula; ; superior surface of tongue; ; mesenteric lymph nodes; ; ascending aorta; ; aortic valve; ; choroid plexus of fourth ventricle; ; gallbladder; ; vestibular membrane of cochlear duct; ; cumulus cell; ; adrenal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	lipid transporter activity; phospholipase activator activity; beta-N-acetylgalactosaminidase activity; beta-N-acetylhexosaminidase activity; enzyme activator activity; hydrolase activity; sphingolipid activator protein activity;
Cellular component	cytoplasm; apical cortex; lysosomal lumen; mitochondrion; potassium:proton exchanging ATPase complex; cytoplasmic side of plasma membrane; lysosome; extracellular exosome; extracellular region; azurophil granule lumen; basolateral plasma membrane; apical plasma membrane;
Biological process	positive regulation of hydrolase activity; lipid transport; glycosphingolipid metabolic process; neuromuscular process controlling balance; lipid metabolism; lipid storage; nervous system process; learning or memory; oligosaccharide catabolic process; ganglioside metabolic process; ganglioside catabolic process; sphingolipid metabolic process; neutrophil degranulation; positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	2760
	14667
	ENSG00000196743
	ENSMUSG00000000594
	P17900
	Q60648
	NM_001167607; NM_000405
	NM_010299
	NP_000396; NP_001161079
	NP_034429
	Wikidata
View/Edit Human	View/Edit Mouse

GM2 ganglioside activator also known as GM2A is a protein which in humans is encoded by the GM2A gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196743 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000594 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li SC, Nakamura T, Ogamo A, Li YT (November 1979). "Evidence for the presence of two separate protein activators for the enzymic hydrolysis of GM1 and GM2 gangliosides". J. Biol. Chem. 254 (21): 10592–5. doi:10.1016/S0021-9258(19)86559-6. PMID 115863.
^ Klima H, Tanaka A, Schnabel D, Nakano T, Schröder M, Suzuki K, Sandhoff K (September 1991). "Characterization of full-length cDNAs and the gene coding for the human GM2 activator protein". FEBS Lett. 289 (2): 260–4. doi:10.1016/0014-5793(91)81084-L. PMID 1915857. S2CID 40408626.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196743 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000594 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid115863-5] Li SC, Nakamura T, Ogamo A, Li YT (November 1979). "Evidence for the presence of two separate protein activators for the enzymic hydrolysis of GM1 and GM2 gangliosides". J. Biol. Chem. 254 (21): 10592–5. doi:10.1016/S0021-9258(19)86559-6. PMID 115863.

[pmid1915857-6] Klima H, Tanaka A, Schnabel D, Nakano T, Schröder M, Suzuki K, Sandhoff K (September 1991). "Characterization of full-length cDNAs and the gene coding for the human GM2 activator protein". FEBS Lett. 289 (2): 260–4. doi:10.1016/0014-5793(91)81084-L. PMID 1915857. S2CID 40408626.

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