GNB2

GNB2
Identifiers
Aliases	GNB2, G protein subunit beta 2, SSS4, SSS4; NEDHYDF, HG2C1
External IDs	OMIM: 139390; MGI: 95784; HomoloGene: 68451; GeneCards: GNB2; OMA:GNB2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,679,174 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; anterior pituitary; ; granulocyte; ; stromal cell of endometrium; ; skin of leg; ; ganglionic eminence; ; right uterine tube; ; olfactory zone of nasal mucosa; ; skin of abdomen; ; ectocervix;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; calcium channel regulator activity; signal transducer activity; protein binding; GTPase activity; GTPase binding;
Cellular component	cytoplasm; cell body; vesicle; membrane; focal adhesion; myelin sheath; plasma membrane; lysosomal membrane; perinuclear region of cytoplasm; extracellular exosome; cytosol; extracellular space; protein-containing complex;
Biological process	G protein-coupled receptor signaling pathway; cellular response to glucagon stimulus; signal transduction; protein folding; regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	2783
	14693
	ENSG00000172354
	n/a
	P62879
	P62880
	NM_005273
	NM_010312
	NP_005264
	NP_034442
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene.^[4]^[5]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes.

This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172354 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
^ ^a ^b "Entrez Gene: GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172354 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799793-4] Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.

[entrez-5] "Entrez Gene: GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2".

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