Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 is a protein that in humans is encoded by the GNB3 gene.[5][6]
Heterotrimeric guanine nucleotide-binding proteins ( G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000111664 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023439 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Siffert W (Dec 2001). "Molecular genetics of G proteins and atherosclerosis risk". Basic Res Cardiol. 96 (6): 606–11. doi:10.1007/s003950170012. PMID 11770079. S2CID 21235423.
- ^ Weinstein LS, Chen M, Xie T, Liu J (May 2006). "Genetic diseases associated with heterotrimeric G proteins". Trends Pharmacol Sci. 27 (5): 260–6. doi:10.1016/j.tips.2006.03.005. PMID 16600389.
- ^ "Entrez Gene: GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3".