Protein-coding gene in the species Homo sapiens
Granulysin (GNLY) is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic granules.[3][4] It is a pore-forming peptide, as it can puncture a microbial cell wall, allowing for other death-inducing enzymes to enter the microbe and cause microptosis.[3] GNLY is inhibited by cholesterol, and is most effective in helping to kill cholesterol-deficient microbes.[5]
It is part of the saponin-like protein family, and its gene is found on the 2nd chromosome in humans.[3] It is distinguished by its 5 α-helical structure. Its expression is restricted to cytotoxic immune cells such as cytotoxic T cells, NK cells, NKT cells and γδ T cells.[4][3] Orthologs of this protein are found in most mammal species, such as in cows and pigs, however not in rodents.[5][3][4]
Granulysin is also an active player in many diseases, including Leprosy and Toxic Epidermal Necrolysis.[3]