GPA33

GPA33
Identifiers
Aliases	GPA33, A33, glycoprotein A33
External IDs	OMIM: 602171; MGI: 1891703; HomoloGene: 4245; GeneCards: GPA33; OMA:GPA33 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	167,166,479 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	165,994,079 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of transverse colon; ; rectum; ; jejunal mucosa; ; mucosa of sigmoid colon; ; duodenum; ; appendix; ; epithelium of colon; ; granulocyte; ; blood;
	Top expressed in
	intestinal villus; ; left colon; ; crypt of lieberkuhn of small intestine; ; jejunum; ; basilar part of occipital bone; ; duodenum; ; ileum; ; transitional epithelium of urinary bladder; ; humerus; ; Meckel's cartilage;
	More reference expression data
	More reference expression data
Orthologs
	10223
	59290
	ENSG00000143167
	ENSMUSG00000000544
	Q99795
	Q9JKA5
	NM_005814
	NM_021610; NM_001360925; NM_001360926
	NP_005805
	NP_067623; NP_001347854; NP_001347855
	Wikidata
View/Edit Human	View/Edit Mouse

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.^[5]^[6]^[7]

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143167 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000544 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A. 94 (2): 469–74. Bibcode:1997PNAS...94..469H. doi:10.1073/pnas.94.2.469. PMC 19536. PMID 9012807.
^ Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713.
^ ^a ^b "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143167 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000544 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9012807-5] Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A. 94 (2): 469–74. Bibcode:1997PNAS...94..469H. doi:10.1073/pnas.94.2.469. PMC 19536. PMID 9012807.

[pmid9245713-6] Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713.

[entrez-7] "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)".

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