GPR1

CMKLR2
Identifiers
Aliases	CMKLR2, G protein-coupled receptor 1, chemerin chemokine-like receptor 2, GPR1
External IDs	OMIM: 600239; MGI: 2385324; HomoloGene: 21094; GeneCards: CMKLR2; OMA:CMKLR2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	206,218,047 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	63,253,702 bp
RNA expression pattern
	Top expressed in
	placenta; ; stromal cell of endometrium; ; testicle; ; mucosa of esophagus; ; skin of leg; ; right adrenal cortex; ; ventricular zone; ; left adrenal gland; ; gallbladder; ; left adrenal cortex;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; placenta; ; urethra; ; female urethra; ; decidua; ; male urethra; ; epithelium of urethra; ; epithelium of male urethra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide binding; signal transducer activity; protein binding; G protein-coupled receptor activity; peptide binding;
Cellular component	membrane; integral component of membrane; integral component of plasma membrane; neuron projection; plasma membrane; intracellular membrane-bounded organelle; nucleoplasm;
Biological process	chemical synaptic transmission; neuropeptide signaling pathway; G protein-coupled receptor signaling pathway; signal transduction; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
	Sources:Amigo / QuickGO
Orthologs
	2825
	241070
	ENSG00000183671; ENSG00000283448
	ENSMUSG00000046856
	P46091
	Q8K087
NM_001098199; NM_001261452; NM_001261453; NM_001261454; NM_001261455;
	NM_005279; NM_001389445
	NM_146250; NM_001357045
NP_001091669; NP_001248381; NP_001248382; NP_001248383; NP_001248384;
	NP_005270
	NP_666362; NP_001343974
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene.^[5]^[6]

GPR1 is a member of the G protein-coupled receptor family of transmembrane receptors. It functions as a receptor for chemerin.^[7] Other receptors for chemerin include CMKLR1 and CCRL2.

^ ^a ^b ^c ENSG00000283448 GRCh38: Ensembl release 89: ENSG00000183671, ENSG00000283448 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046856 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR1 G protein-coupled receptor 1".
^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (October 1994). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
^ Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ (January 2008). "The genetic design of signaling cascades to record receptor activation". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 64–9. doi:10.1073/pnas.0710487105. PMC 2224232. PMID 18165312.

[refGRCh38Ensembl-1] ENSG00000283448 GRCh38: Ensembl release 89: ENSG00000183671, ENSG00000283448 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046856 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR1 G protein-coupled receptor 1".

[pmid7851889-6] Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (October 1994). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.

[pmid18165312-7] Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ (January 2008). "The genetic design of signaling cascades to record receptor activation". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 64–9. doi:10.1073/pnas.0710487105. PMC 2224232. PMID 18165312.

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