GPR124

ADGRA2
Identifiers
AliasesADGRA2, G protein-coupled receptor 124, TEM5, GPR124, adhesion G protein-coupled receptor A2
External IDsOMIM: 606823; MGI: 1925810; HomoloGene: 13112; GeneCards: ADGRA2; OMA:ADGRA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032777

NM_054044

RefSeq (protein)

NP_116166

NP_473385

Location (UCSC)Chr 8: 37.78 – 37.84 MbChr 8: 27.58 – 27.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.[5][6][7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8][9][10]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000020181Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031486Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Research. 61 (18): 6649–6655. PMID 11559528.
  6. ^ Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochemical and Biophysical Research Communications. 301 (3): 725–734. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
  7. ^ "Entrez Gene: GPR124 G protein-coupled receptor 124".
  8. ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
  9. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
  10. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.