GPR139

GPR139
Identifiers
Aliases	GPR139, GPRg1, PGR3, G protein-coupled receptor 139
External IDs	OMIM: 618448; MGI: 2685341; HomoloGene: 45860; GeneCards: GPR139; OMA:GPR139 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	20,073,890 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	118,783,826 bp
RNA expression pattern
	Top expressed in
	testicle; ; caudate nucleus; ; putamen; ; nucleus accumbens; ; hypothalamus; ; bone marrow; ; substantia nigra; ; pituitary gland; ; C1 segment; ; muscle tissue;
	Top expressed in
	lumbar spinal ganglion; ; habenula; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; mammillary body; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; central gray substance of midbrain; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein dimerization activity; signal transducer activity; neuropeptide receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; neuropeptide signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	124274
	209776
	ENSG00000180269
	ENSMUSG00000066197
	Q6DWJ6
	Q80UC8
	NM_001002911; NM_001318483
	NM_001024138
	NP_001002911; NP_001305412
	NP_001019309
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene.^[5]^[6] Research has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180269 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066197 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, et al. (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–4908. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
^ "Entrez Gene: GPR139 G protein-coupled receptor 139".
^ Dao M, Stoveken HM, Cao Y, Martemyanov KA (March 2022). "The role of orphan receptor GPR139 in neuropsychiatric behavior". Neuropsychopharmacology. 47 (4): 902–913. doi:10.1038/s41386-021-00962-2. PMC 8882194. PMID 33479510. S2CID 231668867.
^ Vedel L, Nøhr AC, Gloriam DE, Bräuner-Osborne H. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):35-46. doi:10.1111/bcpt.13263 PMID 31132229

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180269 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066197 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12679517-5] Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, et al. (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–4908. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.

[entrez-6] "Entrez Gene: GPR139 G protein-coupled receptor 139".

[7] Dao M, Stoveken HM, Cao Y, Martemyanov KA (March 2022). "The role of orphan receptor GPR139 in neuropsychiatric behavior". Neuropsychopharmacology. 47 (4): 902–913. doi:10.1038/s41386-021-00962-2. PMC 8882194. PMID 33479510. S2CID 231668867.

[8] Vedel L, Nøhr AC, Gloriam DE, Bräuner-Osborne H. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):35-46. doi:10.1111/bcpt.13263 PMID 31132229

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