G protein-coupled receptor 15 is a protein that in humans is encoded by the GPR15 gene.
GPR15 is a class A orphan G protein-coupled receptor (heterotrimeric guanine nucleotide-binding protein, GPCR). The GPR15 gene is localized at chromosome 3q11.2-q13.1.[5][6] It is found in epithelial cells,[7] synovial macrophages,[8] endothelial cells [9] and lymphocytes especially T cells.
From the mRNA sequence a 40.8 kD molecular weight of GPR15 is proposed. In an epithelial tumour cell line (HT-29), however, a 36 kD band, composed of GPR15 and galactosyl ceramide, was detected. [7] Protein expression in lymphocytes is strongly associated with hypomethylation of its gene. [10]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Heiber M, Marchese A, Nguyen T, Heng HH, George SR, O'Dowd BF (March 1996). "A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3". Genomics. 32 (3): 462–465. doi:10.1006/geno.1996.0143. PMID8838812.
