GPR174

GPR174
Identifiers
Aliases	GPR174, GPCR17, LYPSR3, FKSG79, G protein-coupled receptor 174
External IDs	OMIM: 300903; MGI: 2685222; HomoloGene: 13059; GeneCards: GPR174; OMA:GPR174 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	79,175,318 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	106,340,375 bp
RNA expression pattern
	Top expressed in
	thymus; ; mucosa of ileum; ; lymph node; ; granulocyte; ; appendix; ; epithelium of nasopharynx; ; epithelium of colon; ; spleen; ; superficial temporal artery; ; blood;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; blood; ; thymus; ; lumbar spinal ganglion; ; subcutaneous adipose tissue; ; lumbar subsegment of spinal cord; ; granulocyte; ; white adipose tissue; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; bioactive lipid receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; T cell homeostasis; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84636
	213439
	ENSG00000147138
	ENSMUSG00000073008
	Q9BXC1
	Q3U507
	NM_032553
	NM_001033251; NM_001177781; NM_001177782; NM_001358747
	NP_115942
	NP_001028423; NP_001171252; NP_001171253; NP_001345676
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene.^[5] The receptor has been reported to bind to lysophosphatidylserine. ^[6] ^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147138 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073008 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR174 G protein-coupled receptor 174".
^ Liu G, Li X, Wang Y, Zhang X, Gong W (2023). "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174". PLOS Biol. 21 (12): e3002387. doi:10.1371/journal.pbio.3002387. PMC 10721165. PMID 38048360.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y; et al. (2023). "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling". Nat Commun. 14 (1): 5901. doi:10.1038/s41467-023-41654-3. PMC 10516915. PMID 37737235.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147138 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073008 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR174 G protein-coupled receptor 174".

[pmid38048360-6] Liu G, Li X, Wang Y, Zhang X, Gong W (2023). "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174". PLOS Biol. 21 (12): e3002387. doi:10.1371/journal.pbio.3002387. PMC 10721165. PMID 38048360.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid37737235-7] Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y; et al. (2023). "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling". Nat Commun. 14 (1): 5901. doi:10.1038/s41467-023-41654-3. PMC 10516915. PMID 37737235.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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