GPR182

GPR182
Identifiers
Aliases	GPR182, 7TMR, ADMR, AM-R, AMR, G10D, gamrh, hrhAMR, G protein-coupled receptor 182, L1-R
External IDs	OMIM: 605307; MGI: 109545; HomoloGene: 5255; GeneCards: GPR182; OMA:GPR182 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,998,447 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,587,601 bp
RNA expression pattern
	Top expressed in
	testicle; ; spleen; ; sperm; ; tendon of biceps brachii; ; left adrenal cortex; ; right adrenal cortex; ; tibialis anterior muscle; ; liver; ; right testis; ; left testis;
	Top expressed in
	yolk sac; ; atrium; ; mesenteric lymph nodes; ; right lung; ; liver; ; left lobe of liver; ; right lung lobe; ; endocardial cushion; ; left lung lobe; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	plasma membrane; membrane; intracellular anatomical structure; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; intracellular signal transduction; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	11318
	11536
	ENSG00000166856
	ENSMUSG00000058396
	O15218
	P43142
	NM_007264
	NM_007412
	NP_009195
	NP_031438
	Wikidata
View/Edit Human	View/Edit Mouse

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.^[5]

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.^[6] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).^[7]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166856 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058396 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–4908. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
^ Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID 9367907.
^ Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID 9535752.
^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–339. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID 9620797. S2CID 4364526.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166856 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058396 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12679517-5] Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–4908. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.

[pmid9367907-6] Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID 9367907.

[pmid9535752-7] Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID 9535752.

[pmid9620797-8] McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–339. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID 9620797. S2CID 4364526.

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