GPR183

GPR183
Identifiers
AliasesGPR183, EBI2, G protein-coupled receptor 183, hEBI2
External IDsOMIM: 605741; MGI: 2442034; HomoloGene: 28066; GeneCards: GPR183; OMA:GPR183 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1880

321019

Ensembl

ENSG00000169508

ENSMUSG00000051212

UniProt

P32249

Q3U6B2

RefSeq (mRNA)

NM_004951

NM_183031

RefSeq (protein)

NP_004942

NP_898852

Location (UCSC)Chr 13: 99.29 – 99.31 MbChr 14: 122.19 – 122.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein (GPCR) expressed on the surface of some immune cells, namely B cells and T cells; in humans it is encoded by the GPR183 gene.[5] Expression of EBI2 is one critical mediator of immune cell localization within lymph nodes, responsible in part for the coordination of B cell, T cell, and dendritic cell movement and interaction following antigen exposure.[6][7][8][9] EBI2 is a receptor for oxysterols.[10][11] The most potent activator is 7α,25-dihydroxycholesterol (7α,25-OHC), with other oxysterols exhibiting varying affinities for the receptor.[8][7] Oxysterol gradients drive chemotaxis, attracting the EBI2-expressing cells to locations of high ligand concentration.[6][7][8][9] The GPR183 gene was identified due to its upregulation during Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41, hence its name: EBI2.[12]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169508 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051212 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EBI2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)".
  6. ^ a b Barington L, Wanke F, Niss Arfelt K, Holst PJ, Kurschus FC, Rosenkilde MM (August 2018). "EBI2 in splenic and local immune responses and in autoimmunity". Journal of Leukocyte Biology. 104 (2): 313–322. doi:10.1002/JLB.2VMR1217-510R. PMID 29741800. S2CID 13699151.
  7. ^ a b c Kurschus FC, Wanke F (October 2018). "EBI2 - Sensor for dihydroxycholesterol gradients in neuroinflammation". Biochimie. "Current trends in oxysterols and related sterols". 153: 52–55. doi:10.1016/j.biochi.2018.04.014. PMID 29689289. S2CID 13855522.
  8. ^ a b c Gatto D, Brink R (July 2013). "B cell localization: regulation by EBI2 and its oxysterol ligand". Trends in Immunology. 34 (7): 336–341. doi:10.1016/j.it.2013.01.007. PMID 23481574.
  9. ^ a b Daugvilaite V, Arfelt KN, Benned-Jensen T, Sailer AW, Rosenkilde MM (July 2014). "Oxysterol-EBI2 signaling in immune regulation and viral infection". European Journal of Immunology. 44 (7): 1904–1912. doi:10.1002/eji.201444493. PMC 4209795. PMID 24810762.
  10. ^ Liu C, Yang XV, Wu J, Kuei C, Mani NS, Zhang L, et al. (July 2011). "Oxysterols direct B-cell migration through EBI2". Nature. 475 (7357): 519–523. doi:10.1038/nature10226. PMID 21796211. S2CID 4414566.
  11. ^ Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, et al. (July 2011). "Oxysterols direct immune cell migration via EBI2". Nature. 475 (7357): 524–527. doi:10.1038/nature10280. PMC 4297623. PMID 21796212.
  12. ^ Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (April 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". Journal of Virology. 67 (4): 2209–2220. doi:10.1128/JVI.67.4.2209-2220.1993. PMC 240341. PMID 8383238.