GPR3

GPR3
Identifiers
Aliases	GPR3, ACCA, G protein-coupled receptor 3
External IDs	OMIM: 600241; MGI: 101908; HomoloGene: 31303; GeneCards: GPR3; OMA:GPR3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,395,814 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,939,847 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; testicle; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; right hemisphere of cerebellum; ; islet of Langerhans; ; primary visual cortex; ; right auricle;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; facial motor nucleus; ; superior frontal gyrus; ; primary visual cortex; ; embryo; ; morula; ; morula; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; regulation of meiotic nuclear division; adenylate cyclase-activating G protein-coupled receptor signaling pathway; signal transduction; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2827
	14748
	ENSG00000181773
	ENSMUSG00000049649
	P46089
	P35413
	NM_005281
	NM_008154
	NP_005272
	NP_032180
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene.^[5]^[6] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

GPR3 mRNA is broadly expressed in neurons in various brain regions, including the cortex, thalamus, hypothalamus, amygdala, hippocampus, pituitary, and cerebellum.^[7]^[8] GPR3 mRNA is also expressed in the eye, lung, kidney, liver, testes, and ovary, among other tissues.^[9]

Individuals afflicted by Alzheimer's disease have in many cases, overexpression of the GPR3 protein in their neurons.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181773 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049649 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, et al. (October 1994). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–618. doi:10.1006/geno.1994.1549. PMID 7851889.
^ "Entrez Gene: GPR3 G protein-coupled receptor 3".
^ Iismaa TP, Kiefer J, Liu ML, Baker E, Sutherland GR, Shine J (November 1994). "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system". Genomics. 24 (2): 391–394. doi:10.1006/geno.1994.1635. PMID 7698767.
^ Cite error: The named reference pmid16229830 was invoked but never defined (see the help page).
^ Zhang B, Ding J, Li Y, Wang J, Zhao Y, Wang W, et al. (May 2012). "The porcine Gpr3 gene: molecular cloning, characterization and expression level in tissues and cumulus-oocyte complexes during in vitro maturation". Molecular Biology Reports. 39 (5): 5831–5839. doi:10.1007/s11033-011-1393-y. PMID 22207171. S2CID 18513825.
^ Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, et al. (February 2009). "The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons". Science. 323 (5916): 946–951. Bibcode:2009Sci...323..946T. doi:10.1126/science.1160649. PMID 19213921. S2CID 30276731.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181773 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049649 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7851889-5] Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, et al. (October 1994). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–618. doi:10.1006/geno.1994.1549. PMID 7851889.

[entrez-6] "Entrez Gene: GPR3 G protein-coupled receptor 3".

[Isolation_and_chromosomal_localizat-7] Iismaa TP, Kiefer J, Liu ML, Baker E, Sutherland GR, Shine J (November 1994). "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system". Genomics. 24 (2): 391–394. doi:10.1006/geno.1994.1635. PMID 7698767.

[pmid16229830-8] Cite error: The named reference pmid16229830 was invoked but never defined (see the help page).

[9] Zhang B, Ding J, Li Y, Wang J, Zhao Y, Wang W, et al. (May 2012). "The porcine Gpr3 gene: molecular cloning, characterization and expression level in tissues and cumulus-oocyte complexes during in vitro maturation". Molecular Biology Reports. 39 (5): 5831–5839. doi:10.1007/s11033-011-1393-y. PMID 22207171. S2CID 18513825.

[10] Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, et al. (February 2009). "The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons". Science. 323 (5916): 946–951. Bibcode:2009Sci...323..946T. doi:10.1126/science.1160649. PMID 19213921. S2CID 30276731.

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