GPR35

GPR35
Identifiers
Aliases	GPR35, G protein-coupled receptor 35
External IDs	OMIM: 602646; MGI: 1929509; HomoloGene: 3874; GeneCards: GPR35; OMA:GPR35 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	240,633,159 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	92,914,113 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; mucosa of ileum; ; duodenum; ; jejunal mucosa; ; granulocyte; ; right uterine tube; ; monocyte; ; rectum; ; body of stomach; ; mucosa of sigmoid colon;
	Top expressed in
	zygote; ; lumbar spinal ganglion; ; primary oocyte; ; secondary oocyte; ; neural layer of retina; ; urethra; ; granulocyte; ; esophagus; ; yolk sac; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; C-X-C chemokine receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; cytoskeleton organization; positive regulation of cytosolic calcium ion concentration; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; negative regulation of neuronal action potential;
	Sources:Amigo / QuickGO
Orthologs
	2859
	64095
	ENSG00000178623
	ENSMUSG00000026271
	Q9HC97
	Q9ES90
	NM_005301; NM_001195381; NM_001195382; NM_001394730
	NM_001104529; NM_001271766; NM_022320
	NP_001182310; NP_001182311; NP_005292
	NP_001097999; NP_001258695; NP_071715
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene.^[5] Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178623 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026271 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, et al. (January 1998). "Discovery of three novel G-protein-coupled receptor genes". Genomics. 47 (2): 310–313. doi:10.1006/geno.1998.5095. PMID 9479505.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178623 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026271 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9479505-5] O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, et al. (January 1998). "Discovery of three novel G-protein-coupled receptor genes". Genomics. 47 (2): 310–313. doi:10.1006/geno.1998.5095. PMID 9479505.

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