GPR37

GPR37
Identifiers
AliasesGPR37, EDNRBL, PAELR, hET(B)R-LP, G protein-coupled receptor 37
External IDsOMIM: 602583; MGI: 1313297; HomoloGene: 3875; GeneCards: GPR37; OMA:GPR37 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005302

NM_010338

RefSeq (protein)

NP_005293

NP_034468

Location (UCSC)Chr 7: 124.74 – 124.77 MbChr 6: 25.67 – 25.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.[5][6][7] GPR37 is primarily found in the central nervous system (CNS), with significant expression observed in various CNS regions including the amygdala, basal ganglia (caudate, putamen, and nucleus accumbens), substantia nigra, hippocampus, frontal cortex, and hypothalamus, particularly noteworthy is its exceptionally elevated expression in the spinal cord.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170775Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039904Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (October 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.
  6. ^ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".
  7. ^ Bolinger AA, Frazier A, La JH, Allen JA, Zhou J (September 2023). "Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target". ACS Chemical Neuroscience. 14 (18): 3318–3334. doi:10.1021/acschemneuro.3c00479. PMC 11144446. PMID 37676000. S2CID 261580509.
  8. ^ Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, et al. (GTEx Consortium) (June 2013). "The Genotype-Tissue Expression (GTEx) project". Nature Genetics. 45 (6): 580–585. doi:10.1038/ng.2653. PMC 4010069. PMID 23715323.