GPR55

GPR55
Identifiers
Aliases	GPR55, LPIR1, G protein-coupled receptor 55
External IDs	OMIM: 604107; MGI: 2685064; HomoloGene: 36184; GeneCards: GPR55; OMA:GPR55 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	230,961,066 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	85,961,007 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; nucleus accumbens; ; lymph node; ; spleen; ; putamen; ; caudate nucleus; ; right testis; ; appendix; ; blood;
	Top expressed in
	jejunum; ; duodenum; ; ileum; ; colon; ; spermatocyte; ; testicle; ; adrenal gland; ; yolk sac; ; primary oocyte; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	cannabinoid receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	positive regulation of Rho protein signal transduction; G protein-coupled receptor signaling pathway; activation of phospholipase C activity; bone resorption; negative regulation of osteoclast differentiation; signal transduction; positive regulation of ERK1 and ERK2 cascade; cannabinoid signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9290
	227326
	ENSG00000135898
	ENSMUSG00000049608
	Q9Y2T6
	Q3UJF0
	NM_005683
	NM_001033290
	NP_005674
	NP_001028462
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor 55 also known as GPR55 is a G protein-coupled receptor that in humans is encoded by the GPR55 gene.^[5]

GPR55, along with GPR119 and GPR18, have been implicated as novel cannabinoid receptors.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135898 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049608 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR55 G protein-coupled receptor 55".
^ Brown AJ (Nov 2007). "Novel cannabinoid receptors". British Journal of Pharmacology. 152 (5): 567–75. doi:10.1038/sj.bjp.0707481. PMC 2190013. PMID 17906678.
^ McHugh D, Hu SS, Rimmerman N, Juknat A, Vogel Z, Walker JM, Bradshaw HB (March 2010). "N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor". BMC Neuroscience. 11: 44. doi:10.1186/1471-2202-11-44. PMC 2865488. PMID 20346144.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135898 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049608 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR55 G protein-coupled receptor 55".

[pmid17906678-6] Brown AJ (Nov 2007). "Novel cannabinoid receptors". British Journal of Pharmacology. 152 (5): 567–75. doi:10.1038/sj.bjp.0707481. PMC 2190013. PMID 17906678.

[pmid20346144-7] McHugh D, Hu SS, Rimmerman N, Juknat A, Vogel Z, Walker JM, Bradshaw HB (March 2010). "N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor". BMC Neuroscience. 11: 44. doi:10.1186/1471-2202-11-44. PMC 2865488. PMID 20346144.

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