G protein-coupled receptor 56 also known as TM7XN1 is a protein encoded by the ADGRG1 gene.[5] GPR56 is a member of the adhesion GPCR family.[6][7] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8]
GPR56 is expressed in liver, muscle, tendon, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic precursor, muscle, and developing neural cells in the mouse.[9] GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development.[10][11] More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells.[12]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000205336 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031785 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
- ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
- ^ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
- ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
- ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
- ^ Xu L (2010). "GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression". Adhesion-GPCRS. Advances in Experimental Medicine and Biology. Vol. 706. pp. 98–108. doi:10.1007/978-1-4419-7913-1_8. ISBN 978-1-4419-7912-4. PMID 21618829.
- ^ Strokes N, Piao X (2010). "Adhesion-GPCRS in the CNS". Adhesion-GPCRS. Advances in Experimental Medicine and Biology. Vol. 706. pp. 87–97. doi:10.1007/978-1-4419-7913-1_7. ISBN 978-1-4419-7912-4. PMID 21618828.
- ^ Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, et al. (October 2011). "Specific expression of GPR56 by human cytotoxic lymphocytes". Journal of Leukocyte Biology. 90 (4): 735–40. doi:10.1189/jlb.0211092. PMID 21724806. S2CID 2885203.