GPR97

ADGRG3
Identifiers
Aliases	ADGRG3, PB99, PGR26, GPR97, adhesion G protein-coupled receptor G3
External IDs	OMIM: 618441; MGI: 1859670; HomoloGene: 18129; GeneCards: ADGRG3; OMA:ADGRG3 - orthologs
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	95,771,878 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; bone marrow; ; right lung; ; bone marrow cells; ; upper lobe of left lung; ; left uterine tube; ; periodontal fiber; ; appendix; ; trabecular bone;
	Top expressed in
	granulocyte; ; endothelial cell of lymphatic vessel; ; tibiofemoral joint; ; bone marrow; ; gastrula; ; decidua; ; embryo; ; yolk sac; ; medullary collecting duct; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; membrane; plasma membrane; specific granule membrane; integral component of plasma membrane;
Biological process	negative regulation of NIK/NF-kappaB signaling; G protein-coupled receptor signaling pathway; B cell differentiation; cell surface receptor signaling pathway; negative regulation of CREB transcription factor activity; regulation of cell migration; signal transduction; neutrophil degranulation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	222487
	54672
	n/a
	ENSMUSG00000060470
	Q86Y34
	Q8R0T6
	NM_001308360; NM_170776
	NM_173036; NM_025309
	NP_001295289; NP_740746
	NP_766624
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene.^[4]^[5]^[6]^[7] GPR97 is a member of the adhesion GPCR family.^[8]^[9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[10]

GPR97 is expressed in human granulocytes and endothelial cells of the vasculature as well as in mouse granulocytes, monocytes, macrophages, and dendritic cells.^[7]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060470 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ Kuźnicki J, Kuźnicki L, Drabikowski W (Jan 1979). "Ca2+-binding modulator protein in protozoa and myxomycete". Cell Biology International Reports. 3 (1): 17–23. doi:10.1016/0309-1651(79)90064-X. PMID 222487.
^ "Entrez Gene: GPR97 G protein-coupled receptor 97".
^ ^a ^b Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000060470 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12435584-4] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[pmid222487-5] Kuźnicki J, Kuźnicki L, Drabikowski W (Jan 1979). "Ca2+-binding modulator protein in protozoa and myxomycete". Cell Biology International Reports. 3 (1): 17–23. doi:10.1016/0309-1651(79)90064-X. PMID 222487.

[entrez-6] "Entrez Gene: GPR97 G protein-coupled receptor 97".

[ReferenceA-7] Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.

[isbn1-4419-7912-3-8] Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[9] Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.

[pmid22333914-10] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

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