GPRC5A

GPRC5A
Identifiers
Aliases	GPRC5A, GPCR5A, RAI3, RAIG1, PEIG-1, TIG1, G protein-coupled receptor class C group 5 member A
External IDs	OMIM: 604138; MGI: 1891250; HomoloGene: 2961; GeneCards: GPRC5A; OMA:GPRC5A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	12,917,937 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	135,061,707 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; lower lobe of lung; ; mucosa of sigmoid colon; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; mucosa of urinary bladder; ; visceral pleura; ; cartilage tissue; ; rectum;
	Top expressed in
	right lung lobe; ; left lung lobe; ; large intestine; ; colon; ; epithelium of stomach; ; left colon; ; blastocyst; ; tail of embryo; ; renal calyx; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity; cadherin binding; protein kinase activator activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; cytoplasmic vesicle membrane; intracellular membrane-bounded organelle; membrane; cytoplasmic vesicle; vesicle; nucleolus; receptor complex;
Biological process	negative regulation of epidermal growth factor-activated receptor activity; G protein-coupled receptor signaling pathway; signal transduction; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	9052
	232431
	ENSG00000013588
	ENSMUSG00000046733
	Q8NFJ5
	Q8BHL4
	NM_003979
	NM_181444
	NP_003970
	NP_852109
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.^[5]^[6] This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG-1);^[7] two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1).^[5] Its encoded protein was later named Retinoic acid-induced protein 3.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013588 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046733 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
^ "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A".
^ Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand). 42 (5): 797–804. PMID 8832110.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000013588 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046733 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9857033-5] Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.

[entrez-6] "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A".

[pmid8832110-7] Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand). 42 (5): 797–804. PMID 8832110.

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