GRIA1

GRIA1
Identifiers
Aliases	GRIA1, GLUH1, GLUR1, GLURA, GluA1, HBGR1, glutamate ionotropic receptor AMPA type subunit 1, Glutamate receptor, ionotropic, AMPA 1
External IDs	OMIM: 138248; MGI: 95808; HomoloGene: 20226; GeneCards: GRIA1; OMA:GRIA1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	153,813,869 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	57,221,070 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; optic nerve; ; middle temporal gyrus; ; ganglionic eminence; ; paraflocculus of cerebellum; ; ventricular zone; ; right hemisphere of cerebellum; ; entorhinal cortex; ; prefrontal cortex; ; Brodmann area 46;
	Top expressed in
	lateral septal nucleus; ; subiculum; ; dentate gyrus; ; ventromedial nucleus; ; Region I of hippocampus proper; ; anterior amygdaloid area; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; CA3 field; ; entorhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	glutamate receptor activity; PDZ domain binding; AMPA glutamate receptor activity; ion channel activity; protein binding; ionotropic glutamate receptor activity; extracellularly glutamate-gated ion channel activity; excitatory extracellular ligand-gated ion channel activity; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; amyloid-beta binding; signaling receptor activity;
Cellular component	integral component of membrane; recycling endosome; endocytic vesicle membrane; postsynaptic membrane; cell projection; endoplasmic reticulum membrane; membrane; synaptic vesicle; postsynaptic density; axonal spine; plasma membrane; dendritic spine; synapse; dendrite membrane; cell surface; cell junction; soma; dendrite; endoplasmic reticulum; dendritic spine membrane; neuron spine; ER to Golgi transport vesicle membrane; neuron projection; AMPA glutamate receptor complex; ionotropic glutamate receptor complex; endoplasmic reticulum-Golgi intermediate compartment membrane; Golgi membrane; postsynapse; postsynaptic density membrane; endosome; early endosome membrane; somatodendritic compartment; recycling endosome membrane; synaptic membrane; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	receptor internalization; ion transport; endoplasmic reticulum to Golgi vesicle-mediated transport; ion transmembrane transport; COPII vesicle coating; long-term memory; transport; long-term depression; signal transduction; chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; regulation of postsynaptic membrane potential; regulation of postsynaptic cytosolic calcium ion concentration; chemical synaptic transmission, postsynaptic; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2890
	14799
	ENSG00000155511
	ENSMUSG00000020524
	P42261
	P23818
NM_000827; NM_001114183; NM_001258019; NM_001258020; NM_001258021;
	NM_001258022; NM_001258023; NM_001364165; NM_001364166; NM_001364167
	NM_001113325; NM_001252403; NM_008165
NP_000818; NP_001107655; NP_001244948; NP_001244949; NP_001244950;
	NP_001244951; NP_001244952; NP_001351094; NP_001351095; NP_001351096
	NP_001106796; NP_001239332; NP_032191
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155511 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020524 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L (October 1991). "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes". Proc Natl Acad Sci U S A. 88 (17): 7557–7561. Bibcode:1991PNAS...88.7557P. doi:10.1073/pnas.88.17.7557. PMC 52340. PMID 1652753.
^ McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF (July 1992). "Chromosomal localization of human glutamate receptor genes". J Neurosci. 12 (7): 2555–2562. doi:10.1523/JNEUROSCI.12-07-02555.1992. PMC 6575855. PMID 1319477.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155511 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020524 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1652753-5] Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L (October 1991). "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes". Proc Natl Acad Sci U S A. 88 (17): 7557–7561. Bibcode:1991PNAS...88.7557P. doi:10.1073/pnas.88.17.7557. PMC 52340. PMID 1652753.

[pmid1319477-6] McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF (July 1992). "Chromosomal localization of human glutamate receptor genes". J Neurosci. 12 (7): 2555–2562. doi:10.1523/JNEUROSCI.12-07-02555.1992. PMC 6575855. PMID 1319477.

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