GRIA4

GRIA4
Identifiers
Aliases	GRIA4, GLUR4, GLUR4C, GLURD, GluA4, glutamate ionotropic receptor AMPA type subunit 4, NEDSGA, GluA4-ATD
External IDs	OMIM: 138246; MGI: 95811; HomoloGene: 20227; GeneCards: GRIA4; OMA:GRIA4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	105,982,092 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	4,796,234 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; anterior cingulate cortex; ; cerebellar vermis; ; right frontal lobe; ; Brodmann area 9; ; pons; ; C1 segment;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; dorsal tegmental nucleus; ; anterior horn of spinal cord; ; deep cerebellar nuclei; ; dorsomedial hypothalamic nucleus; ; medial geniculate nucleus; ; ventral tegmental area; ; medial vestibular nucleus; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; ionotropic glutamate receptor activity; extracellularly glutamate-gated ion channel activity; excitatory extracellular ligand-gated ion channel activity; AMPA glutamate receptor activity; protein binding; amyloid-beta binding; signaling receptor activity;
Cellular component	extracellular vesicle; integral component of membrane; endocytic vesicle membrane; postsynaptic membrane; cell projection; membrane; plasma membrane; synapse; cell junction; dendrite; AMPA glutamate receptor complex; soma; dendritic spine;
Biological process	glutamate receptor signaling pathway; ion transport; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; transport; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2893
	14802
	ENSG00000152578
	ENSMUSG00000025892
	P48058
	Q9Z2W8
	NM_000829; NM_001077243; NM_001077244; NM_001112812
	NM_001113180; NM_001113181; NM_019691
	NP_000820; NP_001070711; NP_001070712; NP_001106283
	NP_001106651; NP_001106652; NP_062665
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4 gene.^[5]

This gene is a member of a family of L-glutamate-gated ion channels that mediate fast synaptic excitatory neurotransmission. These channels are also responsive to the glutamate agonist, alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA). Some haplotypes of this gene show a positive association with schizophrenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5] Like the other AMPA receptor subunits, GluA4 occurs as flip and flop spliced variant.^[6] In addition, GluA4 CTD long and short isoforms exist, and presumably an ATD-only isoform (433 aa).^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152578 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025892 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: GRIA4 glutamate receptor, ionotrophic, AMPA 4".
^ Cite error: The named reference pmid7992055 was invoked but never defined (see the help page).
^ Herbrechter R, Hube N, Buchholz R, Reiner A (July 2021). "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences. 78 (14): 5605–5630. doi:10.1007/s00018-021-03865-z. ISSN 1420-682X. PMC 8257547. PMID 34100982.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152578 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025892 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GRIA4 glutamate receptor, ionotrophic, AMPA 4".

[pmid7992055-6] Cite error: The named reference pmid7992055 was invoked but never defined (see the help page).

[7] Herbrechter R, Hube N, Buchholz R, Reiner A (July 2021). "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences. 78 (14): 5605–5630. doi:10.1007/s00018-021-03865-z. ISSN 1420-682X. PMC 8257547. PMID 34100982.

[1]

[2]

[3]

[4]

[5]

[6]

[7]