GRIK1

GRIK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZNS, 2ZNT, 2ZNU, 3FUZ, 3FV1, 3FV2, 3FVG, 3FVK, 3FVN, 3FVO, 4MF3
Identifiers
Aliases	GRIK1, EAA3, EEA3, GLR5, GLUR5, GluK1, gluR-5, glutamate ionotropic receptor kainate type subunit 1
External IDs	OMIM: 138245; MGI: 95814; HomoloGene: 68992; GeneCards: GRIK1; OMA:GRIK1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	29,940,033 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	88,087,153 bp
RNA expression pattern
	Top expressed in
	testicle; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; frontal pole; ; paraflocculus of cerebellum; ; hypothalamus; ; right frontal lobe;
	Top expressed in
	lumbar spinal ganglion; ; neural layer of retina; ; lateral hypothalamus; ; medial geniculate nucleus; ; suprachiasmatic nucleus; ; pontine nuclei; ; retinal pigment epithelium; ; anterior amygdaloid area; ; barrel cortex; ; lateral geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ion channel activity; kainate selective glutamate receptor activity; extracellularly glutamate-gated ion channel activity; ionotropic glutamate receptor activity; ligand-gated ion channel activity; signaling receptor activity; glutamate receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; cell junction; plasma membrane; postsynaptic membrane; integral component of plasma membrane; synapse; membrane; kainate selective glutamate receptor complex; presynaptic membrane;
Biological process	glutamate receptor signaling pathway; central nervous system development; ion transmembrane transport; regulation of synaptic transmission, glutamatergic; ion transport; nervous system development; chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; synaptic transmission, glutamatergic; modulation of chemical synaptic transmission; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2897
	14805
	ENSG00000171189
	ENSMUSG00000022935
	P39086
	Q60934
NM_000830; NM_175611; NM_001320616; NM_001320618; NM_001320621;
	NM_001320630; NM_001330993; NM_001330994; NM_001393424; NM_001393425; NM_001393426
	NM_010348; NM_146072; NM_001346964
NP_000821; NP_001307545; NP_001307547; NP_001307550; NP_001307559;
	NP_001317922; NP_001317923; NP_783300
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171189 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022935 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GRIK1 glutamate receptor, ionotropic, kainate 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171189 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022935 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GRIK1 glutamate receptor, ionotropic, kainate 1".

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