GRIK2

GRIK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QXM, 5CMM
Identifiers
Aliases	GRIK2, EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6, glutamate ionotropic receptor kainate type subunit 2, NEDLAS
External IDs	OMIM: 138244; MGI: 95815; HomoloGene: 40717; GeneCards: GRIK2; OMA:GRIK2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.3 Start 100,962,701 bp[1] End 102,081,622 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B3|10 24.87 cM Start 49,094,833 bp[2] End 49,788,766 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis cerebellar hemisphere right hemisphere of cerebellum middle temporal gyrus paraflocculus of cerebellum Brodmann area 23 Brodmann area 10 orbitofrontal cortex superior frontal gyrus entorhinal cortex Top expressed in dentate gyrus of hippocampal formation granule cell nucleus accumbens inner renal medulla lumbar subsegment of spinal cord ventricular zone superior frontal gyrus spermatid dorsal striatum cerebellar cortex tongue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutamate receptor activity PDZ domain binding kainate selective glutamate receptor activity protein homodimerization activity ion channel activity ionotropic glutamate receptor activity identical protein binding ligand-gated ion channel activity extracellularly glutamate-gated ion channel activity signaling receptor activity ubiquitin conjugating enzyme binding ubiquitin protein ligase binding ligand-gated ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane perikaryon postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane cell junction terminal bouton axon dendrite dendrite cytoplasm ionotropic glutamate receptor complex postsynaptic density kainate selective glutamate receptor complex presynaptic membrane soma hippocampal mossy fiber to CA3 synapse glutamatergic synapse Biological process neuron apoptotic process glutamate receptor signaling pathway modulation of chemical synaptic transmission ion transport receptor clustering ion transmembrane transport positive regulation of neuron apoptotic process regulation of JNK cascade ionotropic glutamate receptor signaling pathway positive regulation of synaptic transmission excitatory postsynaptic potential negative regulation of synaptic transmission, glutamatergic chemical synaptic transmission behavioral fear response cellular calcium ion homeostasis intracellular protein transport neuronal action potential synaptic transmission, glutamatergic regulation of membrane potential negative regulation of neuron apoptotic process regulation of long-term neuronal synaptic plasticity regulation of short-term neuronal synaptic plasticity inhibitory postsynaptic potential regulation of presynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2898 14806 Ensembl ENSG00000164418 ENSMUSG00000056073 UniProt Q13002 P39087 RefSeq (mRNA) NM_001166247 NM_021956 NM_175768 NM_001111268 NM_010349 RefSeq (protein) NP_001159719 NP_068775 NP_786944 NP_001104738 NP_034479 NP_001345795 Location (UCSC) Chr 6: 100.96 – 102.08 Mb Chr 10: 49.09 – 49.79 Mb PubMed search [3] [4]
Wikidata
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Glutamate ionotropic receptor kainate type subunit 2, also known as ionotropic glutamate receptor 6 or GluR6, is a protein that in humans is encoded by the GRIK2 (or GLUR6) gene.^[5][6][7]