GRIN2B

GRIN2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EWM, 5EWL, 5EWJ
Identifiers
Aliases	GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3, DEE27
External IDs	OMIM: 138252; MGI: 95821; HomoloGene: 646; GeneCards: GRIN2B; OMA:GRIN2B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	13,982,002 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	136,150,509 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Brodmann area 23; ; sural nerve; ; middle temporal gyrus; ; primary visual cortex; ; corpus callosum; ; prefrontal cortex; ; nucleus accumbens; ; endothelial cell; ; dorsolateral prefrontal cortex;
	Top expressed in
	lateral septal nucleus; ; olfactory tubercle; ; lateral geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; anterior amygdaloid area; ; superior frontal gyrus; ; subiculum; ; seminiferous tubule; ; nucleus accumbens; ; primary visual cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; glycine binding; metal ion binding; ion channel activity; protein binding; ionotropic glutamate receptor activity; extracellularly glutamate-gated ion channel activity; NMDA glutamate receptor activity; glutamate binding; glutamate-gated calcium ion channel activity; amyloid-beta binding; signaling receptor activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; synapse; NMDA selective glutamate receptor complex; cell surface; cell junction; neuron projection; intracellular anatomical structure; integral component of plasma membrane; postsynaptic density; plasma membrane; cytoplasm; synaptic membrane; postsynaptic density membrane;
Biological process	glutamate receptor signaling pathway; ephrin receptor signaling pathway; ion transport; MAPK cascade; learning or memory; response to ethanol; chemical synaptic transmission; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; regulation of ion transmembrane transport; transport; calcium-mediated signaling; protein heterotetramerization; regulation of molecular function; calcium ion transmembrane import into cytosol; multicellular organism development; brain development; regulation of synaptic plasticity; long-term potentiation; excitatory chemical synaptic transmission; positive regulation of neuron death; negative regulation of dendritic spine maintenance; positive regulation of cysteine-type endopeptidase activity; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2904
	14812
	ENSG00000273079
	ENSMUSG00000030209
	Q13224
	Q01097
	NM_000834
	NM_008171; NM_001363750
	NP_000825
	NP_032197; NP_001350679
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000273079 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030209 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (May 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. Bibcode:1992Sci...256.1217M. doi:10.1126/science.256.5060.1217. PMID 1350383. S2CID 989677.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000273079 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030209 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1350383-5] Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (May 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. Bibcode:1992Sci...256.1217M. doi:10.1126/science.256.5060.1217. PMID 1350383. S2CID 989677.

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