GRIN2D

GRIN2D
Identifiers
Aliases	GRIN2D, EB11, GluN2D, NMDAR2D, NR2D, glutamate ionotropic receptor NMDA type subunit 2D, EIEE46, DEE46
External IDs	OMIM: 602717; MGI: 95823; HomoloGene: 648; GeneCards: GRIN2D; OMA:GRIN2D - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,444,931 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,878,378 bp
RNA expression pattern
	Top expressed in
	cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; ganglionic eminence; ; hypothalamus; ; ventricular zone; ; right frontal lobe; ; lateral nuclear group of thalamus; ; amygdala; ; dorsolateral prefrontal cortex;
	Top expressed in
	molecular layer of cerebellar cortex; ; lumbar subsegment of spinal cord; ; molar; ; primary visual cortex; ; seminiferous tubule; ; dorsomedial hypothalamic nucleus; ; superior frontal gyrus; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion channel activity; protein binding; extracellularly glutamate-gated ion channel activity; ionotropic glutamate receptor activity; NMDA glutamate receptor activity; glutamate-gated calcium ion channel activity; signaling receptor activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; intracellular anatomical structure; integral component of plasma membrane; NMDA selective glutamate receptor complex; postsynaptic density membrane;
Biological process	startle response; regulation of sensory perception of pain; adult locomotory behavior; ion transport; MAPK cascade; ionotropic glutamate receptor signaling pathway; excitatory postsynaptic potential; calcium-mediated signaling; calcium ion transmembrane import into cytosol; regulation of molecular function; brain development; regulation of synaptic plasticity; long-term potentiation; excitatory chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2906
	14814
	ENSG00000105464
	ENSMUSG00000002771
	O15399
	Q03391
	NM_000836
	NM_008172
	NP_000827
	NP_032198
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate [NMDA] receptor subunit epsilon-4 is a protein that in humans is encoded by the GRIN2D gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105464 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002771 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (Apr 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5. doi:10.1006/geno.1997.5132. PMID 9480759.
^ Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M (Jan 1998). "Isolation of estrogen-responsive genes with a CpG island library". Mol. Cell. Biol. 18 (1): 442–9. doi:10.1128/mcb.18.1.442. PMC 121513. PMID 9418891.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105464 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002771 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9480759-5] Kalsi G, Whiting P, Bourdelles BL, Callen D, Barnard EA, Gurling H (Apr 1998). "Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels". Genomics. 47 (3): 423–5. doi:10.1006/geno.1997.5132. PMID 9480759.

[pmid9418891-6] Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M (Jan 1998). "Isolation of estrogen-responsive genes with a CpG island library". Mol. Cell. Biol. 18 (1): 442–9. doi:10.1128/mcb.18.1.442. PMC 121513. PMID 9418891.

[entrez-7] Cite error: The named reference entrez was invoked but never defined (see the help page).

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