GSPT1

GSPT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E1Y, 3J5Y, 4D61, 5HXB
Identifiers
Aliases	GSPT1, 551G9.2, ETF3A, GST1, eRF3a, G1 to S phase transition 1
External IDs	OMIM: 139259; MGI: 1316728; HomoloGene: 68226; GeneCards: GSPT1; OMA:GSPT1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	11,916,082 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	11,072,189 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; epithelium of colon; ; trabecular bone; ; islet of Langerhans; ; gastrocnemius muscle; ; ventricular zone; ; mucosa of sigmoid colon; ; blood; ; ganglionic eminence; ; parotid gland;
	Top expressed in
	tail of embryo; ; epiblast; ; ventricular zone; ; abdominal wall; ; somite; ; primitive streak; ; dermis; ; endothelial cell of lymphatic vessel; ; morula; ; seminal vesicula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; translation release factor activity; protein binding; GTPase activity; RNA binding;
Cellular component	translation release factor complex; intracellular anatomical structure; cytosol;
Biological process	G1 phase; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein biosynthesis; cytoplasmic translational termination; protein methylation; translational termination; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	2935
	14852
	ENSG00000103342
	ENSMUSG00000062203
	P15170
	Q8R050
	NM_002094; NM_001130006; NM_001130007
	NM_001130008; NM_146066
	NP_001123478; NP_001123479; NP_002085
	NP_001123480; NP_666178
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103342 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062203 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, Ui M (Dec 1989). "A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells". The EMBO Journal. 8 (12): 3807–14. doi:10.1002/j.1460-2075.1989.tb08558.x. PMC 402068. PMID 2511002.
^ Lee JA, Park JE, Lee DH, Park SG, Myung PK, Park BC, Cho S (Feb 2008). "G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1". Oncogene. 27 (9): 1297–305. doi:10.1038/sj.onc.1210740. PMID 17700517.
^ "Entrez Gene: GSPT1 G1 to S phase transition 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103342 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062203 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2511002-5] Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, Ui M (Dec 1989). "A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells". The EMBO Journal. 8 (12): 3807–14. doi:10.1002/j.1460-2075.1989.tb08558.x. PMC 402068. PMID 2511002.

[pmid17700517-6] Lee JA, Park JE, Lee DH, Park SG, Myung PK, Park BC, Cho S (Feb 2008). "G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1". Oncogene. 27 (9): 1297–305. doi:10.1038/sj.onc.1210740. PMID 17700517.

[entrez-7] "Entrez Gene: GSPT1 G1 to S phase transition 1".

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