GTF2A1

GTF2A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NVP, 5IYB, 5IYC, 5IY9, 5IY8, 5IY7, 5IYD, 5IY6, 5FUR, 5IYA
Identifiers
Aliases	GTF2A1, TF2A1, TFIIA, TFIIA-42, TFIIAL, general transcription factor IIA subunit 1
External IDs	OMIM: 600520; MGI: 1933277; HomoloGene: 56331; GeneCards: GTF2A1; OMA:GTF2A1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	81,221,377 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	91,557,261 bp
RNA expression pattern
	Top expressed in
	tibia; ; corpus epididymis; ; pons; ; trabecular bone; ; jejunal mucosa; ; oral cavity; ; postcentral gyrus; ; caput epididymis; ; Achilles tendon; ; tendon of biceps brachii;
	Top expressed in
	zygote; ; secondary oocyte; ; retinal pigment epithelium; ; spermatocyte; ; genital tubercle; ; spermatid; ; ascending aorta; ; aortic valve; ; tail of embryo; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	TBP-class protein binding; DNA binding; transcription coactivator activity; transcription factor binding; protein binding; protein heterodimerization activity; RNA polymerase II general transcription initiation factor activity;
Cellular component	transcription factor TFIIA complex; nucleus; nucleoplasm; transcription factor TFIID complex; cytosol; cytoplasm;
Biological process	transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; snRNA transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	2957
	83602
	ENSG00000165417
	ENSMUSG00000020962
	P52655
	Q99PM3
	NM_201595; NM_001278940; NM_015859
	NM_031391; NM_175335
	NP_001265869; NP_056943; NP_963889
	NP_113568; NP_780544
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165417 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020962 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ DeJong J, Roeder RG (Nov 1993). "A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA". Genes & Development. 7 (11): 2220–34. doi:10.1101/gad.7.11.2220. PMID 8224848.
^ "Entrez Gene: GTF2A1 general transcription factor IIA, 1, 19/37kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165417 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020962 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8224848-5] DeJong J, Roeder RG (Nov 1993). "A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA". Genes & Development. 7 (11): 2220–34. doi:10.1101/gad.7.11.2220. PMID 8224848.

[entrez-6] "Entrez Gene: GTF2A1 general transcription factor IIA, 1, 19/37kDa".

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