GTF2F1

GTF2F1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F3U, 1I27, 1J2X, 1NHA, 1ONV, 2K7L, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	GTF2F1, general transcription factor IIF, polypeptide 1, 74kDa, BTF4, RAP74, TF2F1, TFIIF, general transcription factor IIF subunit 1
External IDs	OMIM: 189968; MGI: 1923848; HomoloGene: 1585; GeneCards: GTF2F1; OMA:GTF2F1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,393,981 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,318,288 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; left testis; ; right hemisphere of cerebellum; ; right testis; ; left ovary; ; prefrontal cortex; ; anterior pituitary; ; superior frontal gyrus;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; seminiferous tubule; ; neural layer of retina; ; tail of embryo; ; primitive streak; ; primary oocyte; ; yolk sac; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; transcription factor binding; protein binding; phosphatase activator activity; RNA binding; protein phosphatase binding; protein domain specific binding; RNA polymerase II general transcription initiation factor activity; promoter-specific chromatin binding;
Cellular component	intracellular membrane-bounded organelle; nucleoplasm; transcription factor TFIIF complex; cell junction; transcription factor TFIID complex; nucleus; protein-containing complex;
Biological process	mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; transcription elongation from RNA polymerase II promoter; response to virus; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of viral transcription; transcription initiation from RNA polymerase II promoter; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; snRNA transcription by RNA polymerase II; fibroblast growth factor receptor signaling pathway; positive regulation of catalytic activity; RNA metabolic process; negative regulation of protein binding;
	Sources:Amigo / QuickGO
Orthologs
	2962
	98053
	ENSG00000125651
	ENSMUSG00000002658
	P35269
	Q3THK3
	NM_002096
	NM_133801
	NP_002087
	NP_598562
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125651 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002658 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.
^ "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125651 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002658 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1734284-5] Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.

[entrez-6] "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".

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