GTF2H1

GTF2H1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PFJ, 2DII, 2RNR, 2RUK, 2RVB
Identifiers
Aliases	GTF2H1, BTF2, P62, TFB1, TFIIH, general transcription factor IIH subunit 1
External IDs	OMIM: 189972; MGI: 1277216; HomoloGene: 3885; GeneCards: GTF2H1; OMA:GTF2H1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,367,045 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,473,224 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; endometrium; ; tonsil; ; right testis; ; left testis; ; monocyte; ; islet of Langerhans; ; smooth muscle tissue; ; gallbladder;
	Top expressed in
	spermatocyte; ; spermatid; ; yolk sac; ; Rostral migratory stream; ; lacrimal gland; ; genital tubercle; ; neural layer of retina; ; epiblast; ; morula; ; endothelial cell of lymphatic vessel;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; ATP-dependent activity, acting on DNA; chromatin binding; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity;
Cellular component	nucleoplasm; transcription factor TFIIH holo complex; nucleus; transcription factor TFIIH core complex;
Biological process	termination of RNA polymerase I transcription; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-templated; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription, DNA-templated; cellular response to DNA damage stimulus; global genome nucleotide-excision repair; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; nucleotide-excision repair, DNA incision; DNA repair; positive regulation of transcription by RNA polymerase II; nucleotide-excision repair, preincision complex stabilization; nucleotide-excision repair; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; transcription by RNA polymerase I; phosphorylation of RNA polymerase II C-terminal domain; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision, 3'-to lesion; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	2965
	14884
	ENSG00000110768; ENSG00000288114
	ENSMUSG00000006599
	P32780
	Q9DBA9
	NM_001142307; NM_005316
	NM_001291075; NM_008186; NM_001360075; NM_001360076
	NP_001135779; NP_005307
	NP_001278004; NP_032212; NP_001347004; NP_001347005
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000288114 GRCh38: Ensembl release 89: ENSG00000110768, ENSG00000288114 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006599 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM (October 1992). "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science. 257 (5075): 1392–5. Bibcode:1992Sci...257.1392F. doi:10.1126/science.1529339. PMID 1529339.
^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
^ "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa".

[refGRCh38Ensembl-1] ENSG00000288114 GRCh38: Ensembl release 89: ENSG00000110768, ENSG00000288114 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006599 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1529339-5] Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM (October 1992). "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science. 257 (5075): 1392–5. Bibcode:1992Sci...257.1392F. doi:10.1126/science.1529339. PMID 1529339.

[pmid8162052-6] Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.

[entrez-7] "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa".

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