GTF2H2

GTF2H2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z60, 5IVW, 5IY9, 5IY8, 5IY7, 5IY6
Identifiers
Aliases	GTF2H2, BTF2, BTF2P44, T-BTF2P44, TFIIH, p44, general transcription factor IIH subunit 2
External IDs	OMIM: 601748; MGI: 1345669; HomoloGene: 1159; GeneCards: GTF2H2; OMA:GTF2H2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	71,067,689 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	100,629,087 bp
RNA expression pattern
	Top expressed in
	endometrium; ; sural nerve; ; corpus callosum; ; gonad; ; Achilles tendon; ; islet of Langerhans; ; monocyte; ; testicle; ; mucosa of transverse colon; ; smooth muscle tissue;
	Top expressed in
	tail of embryo; ; zygote; ; morula; ; genital tubercle; ; neural layer of retina; ; ventricular zone; ; right kidney; ; embryo; ; embryo; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase activity; ATP-dependent activity, acting on DNA; protein N-terminus binding; DNA-binding transcription factor activity; zinc ion binding; translation factor activity, RNA binding; metal ion binding; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity; nucleic acid binding; RNA polymerase II general transcription initiation factor activity;
Cellular component	nucleoplasm; transcription factor TFIIH holo complex; transcription factor TFIIH core complex; core TFIIH complex portion of holo TFIIH complex; nucleus; transcription factor TFIID complex; nuclear speck;
Biological process	termination of RNA polymerase I transcription; G protein-coupled receptor internalization; regulation of transcription, DNA-templated; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription, DNA-templated; cellular response to DNA damage stimulus; global genome nucleotide-excision repair; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; nucleotide-excision repair, DNA incision; response to UV; nucleotide-excision repair, preincision complex assembly; DNA repair; protein biosynthesis; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex stabilization; protein phosphorylation; nucleotide-excision repair; regulation of transcription by RNA polymerase II; positive regulation of DNA helicase activity; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision, 3'-to lesion; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	2966
	23894
	ENSG00000145736; ENSG00000276910; ENSG00000275045
	ENSMUSG00000021639
	Q13888
	Q9JIB4
	NM_001515
	NM_022011; NM_001360706
NP_001506; NP_001351496; NP_001351497; NP_001351498; NP_001351499;
	NP_001351500; NP_001351501; NP_001351502
	NP_071294; NP_001347635
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor IIH subunit 2 is a protein that in humans is encoded by the GTF2H2 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000276910, ENSG00000275045 GRCh38: Ensembl release 89: ENSG00000145736, ENSG00000276910, ENSG00000275045 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021639 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Humbert S, van Vuuren H, Lutz Y, Hoeijmakers JH, Egly JM, Moncollin V (June 1994). "p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair". EMBO J. 13 (10): 2393–8. doi:10.1002/j.1460-2075.1994.tb06523.x. PMC 395104. PMID 8194529.
^ "Entrez Gene: GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa".

[refGRCh38Ensembl-1] ENSG00000276910, ENSG00000275045 GRCh38: Ensembl release 89: ENSG00000145736, ENSG00000276910, ENSG00000275045 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021639 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8194529-5] Humbert S, van Vuuren H, Lutz Y, Hoeijmakers JH, Egly JM, Moncollin V (June 1994). "p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair". EMBO J. 13 (10): 2393–8. doi:10.1002/j.1460-2075.1994.tb06523.x. PMC 395104. PMID 8194529.

[entrez-6] "Entrez Gene: GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa".

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