GTF3A

GTF3A
Identifiers
Aliases	GTF3A, AP2, TFIIIA, general transcription factor IIIA
External IDs	OMIM: 600860; MGI: 1913846; HomoloGene: 55630; GeneCards: GTF3A; OMA:GTF3A - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	27,435,823 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	146,892,424 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; glutes; ; right ventricle; ; middle temporal gyrus; ; apex of heart; ; biceps brachii; ; thoracic diaphragm; ; palpebral conjunctiva; ; body of tongue; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; abdominal wall; ; embryo; ; tail of embryo; ; epiblast; ; primitive streak; ; neural tube; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleic acid binding; DNA binding; metal ion binding; RNA binding; 5S rRNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	rRNA transcription; regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase III; ribosomal large subunit biogenesis; ribosome biogenesis; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2971
	66596
	ENSG00000122034
	ENSMUSG00000016503
	Q92664
	Q8VHT7
	NM_002097
	NM_025652
	NP_002088
	NP_079928
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.^[5]^[6]

It was first purified and identified as the first mammalian gene-specific activator by Roeder in 1980,^[7] and later characterized by Wolffe and Brown in 1988.

The TFIIIA in Xenopus was the first zinc finger protein discovered.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122034 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016503 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, et al. (Jul 1995). "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA". Cytogenetics and Cell Genetics. 70 (3–4): 235–8. doi:10.1159/000134041. PMID 7789179.
^ "Entrez Gene: GTF3A general transcription factor IIIA".
^ Engelke DR, Ng SY, Shastry BS, Roeder RG (Mar 1980). "Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes". Cell. 19 (3): 717–28. doi:10.1016/S0092-8674(80)80048-1. PMID 6153931. S2CID 23955175.
^ Bruno M, Mahgoub M, Macfarlan TS (December 2019). "The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals". Annual Review of Genetics. 53 (1). Annual Reviews: 393–416. doi:10.1146/annurev-genet-112618-043717. PMID 31518518. S2CID 202572327.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122034 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000016503 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7789179-5] Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, et al. (Jul 1995). "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA". Cytogenetics and Cell Genetics. 70 (3–4): 235–8. doi:10.1159/000134041. PMID 7789179.

[entrez-6] "Entrez Gene: GTF3A general transcription factor IIIA".

[pmid6153931-7] Engelke DR, Ng SY, Shastry BS, Roeder RG (Mar 1980). "Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes". Cell. 19 (3): 717–28. doi:10.1016/S0092-8674(80)80048-1. PMID 6153931. S2CID 23955175.

[Bruno-et-al-2019-8] Bruno M, Mahgoub M, Macfarlan TS (December 2019). "The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals". Annual Review of Genetics. 53 (1). Annual Reviews: 393–416. doi:10.1146/annurev-genet-112618-043717. PMID 31518518. S2CID 202572327.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]