GUCY1A2

GUCY1A2
Identifiers
Aliases	GUCY1A2, GC-SA2, GUC1A2, guanylate cyclase 1, soluble, alpha 2, guanylate cyclase 1 soluble subunit alpha 2
External IDs	OMIM: 601244; MGI: 2660877; HomoloGene: 47953; GeneCards: GUCY1A2; OMA:GUCY1A2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	107,018,476 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	3,894,736 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; lateral nuclear group of thalamus; ; visceral pleura; ; saphenous vein; ; postcentral gyrus; ; tail of epididymis; ; lower lobe of lung; ; external globus pallidus; ; vena cava; ; endothelial cell;
	Top expressed in
	tail of embryo; ; genital tubercle; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; ventricular zone; ; embryo; ; cerebellar cortex; ; spermatid; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP binding; heme binding; nucleotide binding; phosphorus-oxygen lyase activity; lyase activity; protein binding; guanylate cyclase activity; adenylate cyclase activity;
Cellular component	plasma membrane; guanylate cyclase complex, soluble; cytoplasm;
Biological process	signal transduction; intracellular signal transduction; cyclic nucleotide biosynthetic process; cGMP biosynthetic process; positive regulation of nitric oxide mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2977
	234889
	ENSG00000152402
	ENSMUSG00000041624
	P33402
	n/a
	NM_001256424; NM_000855
	NM_001033322
	NP_000846; NP_001243353
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041624 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630. S2CID 84974514.
^ "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041624 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1683630-5] Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi:10.1016/0014-5793(91)80871-Y. PMID 1683630. S2CID 84974514.

[entrez-6] "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

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