GUCY1A3

GUCY1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UVJ, 4NI2
Identifiers
Aliases	GUCY1A1, MYMY6, GC-SA3, GUCY1A3, GUCSA3, guanylate cyclase 1 soluble subunit alpha, guanylate cyclase 1 soluble subunit alpha 1, guanylate cyclase 1, soluble, alpha 3, GUC1A3, GUCA3
External IDs	OMIM: 139396; MGI: 1926562; HomoloGene: 37360; GeneCards: GUCY1A1; OMA:GUCY1A1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	155,732,349 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	82,053,096 bp
RNA expression pattern
	Top expressed in
	urethra; ; vena cava; ; saphenous vein; ; visceral pleura; ; myocardium; ; right ventricle; ; superficial temporal artery; ; lower lobe of lung; ; lactiferous duct; ; middle temporal gyrus;
	Top expressed in
	olfactory tubercle; ; left lung lobe; ; habenula; ; Gonadal ridge; ; ascending aorta; ; aortic valve; ; nucleus accumbens; ; atrium; ; atrioventricular valve; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; guanylate cyclase activity; GTP binding; protein binding; heme binding; lyase activity; phosphorus-oxygen lyase activity; signaling receptor activity; adenylate cyclase activity;
Cellular component	cytoplasm; plasma membrane; guanylate cyclase complex, soluble; glutamatergic synapse; GABA-ergic synapse;
Biological process	intracellular signal transduction; cyclic nucleotide biosynthetic process; blood circulation; regulation of blood pressure; cGMP biosynthetic process; relaxation of vascular associated smooth muscle; nitric oxide mediated signal transduction; positive regulation of nitric oxide mediated signal transduction; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2982
	60596
	ENSG00000164116
	ENSMUSG00000033910
	Q02108; Q6PJR4
	Q9ERL9
NM_000856; NM_001130682; NM_001130683; NM_001130684; NM_001130685;
	NM_001130686; NM_001130687; NM_001256449
	NM_021896; NM_001356987; NM_001356988
NP_000847; NP_001124154; NP_001124155; NP_001124156; NP_001124157;
	NP_001124159; NP_001243378; NP_001366595; NP_001366596; NP_001366597; NP_001366598; NP_001366599; NP_001366600; NP_001366601; NP_001366602; NP_001366603; NP_001366604; NP_001366605
	NP_068696; NP_001343916; NP_001343917
	Wikidata
View/Edit Human	View/Edit Mouse

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164116 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033910 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
^ "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164116 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033910 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1352257-5] Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.

[entrez-6] "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

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