GUCY1B3

GUCY1B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WZ1, 3UVJ, 4NI2
Identifiers
Aliases	GUCY1B1, guanylate cyclase 1, soluble, beta 3, GUCSB3, guanylate cyclase 1 soluble subunit beta, GC-SB3, GUC1B3, GC-S-beta-1, guanylate cyclase 1 soluble subunit beta 1, GUCB3, GUCY1B3
External IDs	OMIM: 139397; MGI: 1860604; HomoloGene: 664; GeneCards: GUCY1B1; OMA:GUCY1B1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	155,807,811 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	81,981,996 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; orbitofrontal cortex; ; lateral nuclear group of thalamus; ; superior frontal gyrus; ; Brodmann area 46; ; postcentral gyrus; ; Brodmann area 23; ; pars compacta; ; pons; ; entorhinal cortex;
	Top expressed in
	olfactory tubercle; ; habenula; ; lateral septal nucleus; ; anterior amygdaloid area; ; globus pallidus; ; left lung lobe; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; dorsal tegmental nucleus; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; guanylate cyclase activity; GTP binding; metal ion binding; protein binding; heme binding; lyase activity; phosphorus-oxygen lyase activity; signaling receptor activity; adenylate cyclase activity;
Cellular component	plasma membrane; guanylate cyclase complex, soluble; cytoplasm; presynaptic active zone;
Biological process	intracellular signal transduction; cyclic nucleotide biosynthetic process; blood circulation; nitric oxide-cGMP-mediated signaling pathway; cGMP biosynthetic process; nitric oxide mediated signal transduction; cellular response to nitric oxide; cGMP-mediated signaling; trans-synaptic signaling by nitric oxide, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2983
	54195
	ENSG00000061918
	ENSMUSG00000028005
	Q02153
	O54865
NM_000857; NM_001291951; NM_001291952; NM_001291953; NM_001291954;
	NM_001291955
	NM_001161796; NM_017469
NP_000848; NP_001278880; NP_001278881; NP_001278882; NP_001278883;
	NP_001278884
	NP_001155268; NP_059497
	Wikidata
View/Edit Human	View/Edit Mouse

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000061918 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028005 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
^ "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000061918 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028005 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1352257-5] Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.

[entrez-6] "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".

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