G protein-coupled bile acid receptor

GPBAR1
Identifiers
Aliases	GPBAR1, BG37, GPCR19, GPR131, M-BAR, TGR5, G protein-coupled bile acid receptor, G protein-coupled bile acid receptor 1
External IDs	OMIM: 610147; MGI: 2653863; HomoloGene: 18125; GeneCards: GPBAR1; OMA:GPBAR1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,263,861 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,318,783 bp
RNA expression pattern
	Top expressed in
	testicle; ; monocyte; ; granulocyte; ; decidua; ; gallbladder; ; blood; ; subcutaneous adipose tissue; ; apex of heart; ; spleen; ; gastric mucosa;
	Top expressed in
	blastocyst; ; embryo; ; embryo; ; yolk sac; ; urinary bladder; ; placenta; ; intestine; ; ileum; ; zygote; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	bile acid receptor activity; G protein-coupled receptor activity; G protein-coupled bile acid receptor activity; signal transducer activity;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; membrane;
Biological process	signal transduction; cell surface bile acid receptor signaling pathway; regulation of bicellular tight junction assembly; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	151306
	227289
	ENSG00000179921
	ENSMUSG00000064272
	Q8TDU6
	Q80SS6
	NM_001077191; NM_001077194; NM_170699; NM_001321950
	NM_174985
	NP_001070659; NP_001070662; NP_001308879; NP_733800
	NP_778150
	Wikidata
View/Edit Human	View/Edit Mouse

The G protein-coupled bile acid receptor 1 (GPBAR1) also known as G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) is a protein that in humans is encoded by the GPBAR1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179921 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000064272 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M (2003). "A G protein-coupled receptor responsive to bile acids". J. Biol. Chem. 278 (11): 9435–40. doi:10.1074/jbc.M209706200. PMID 12524422.
^ Wang H, Tan YZ, Mu RH, Tang SS, Liu X, Xing SY, Long Y, Yuan DH, Hong H (June 2021). "Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum". Biological Psychiatry. 89 (11): 1084–1095. doi:10.1016/j.biopsych.2020.11.018. PMID 33536132. S2CID 227165118.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179921 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000064272 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12524422-5] Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M (2003). "A G protein-coupled receptor responsive to bile acids". J. Biol. Chem. 278 (11): 9435–40. doi:10.1074/jbc.M209706200. PMID 12524422.

[pmid33536132-6] Wang H, Tan YZ, Mu RH, Tang SS, Liu X, Xing SY, Long Y, Yuan DH, Hong H (June 2021). "Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum". Biological Psychiatry. 89 (11): 1084–1095. doi:10.1016/j.biopsych.2020.11.018. PMID 33536132. S2CID 227165118.

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