Galectin-1

LGALS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GZW, 1W6M, 1W6N, 1W6O, 1W6P, 1W6Q, 2KM2, 2ZKN, 3OY8, 3OYW, 3T2T, 3W58, 3W59, 4XBL, 4Q27, 4Q1R, 4Q1P, 4Q2F, 4Q26, 4Y24, 4Y1Z, 4Y22, 4Y20, 4Y1U, 4Y1X, 4Y1Y, 4Y1V
Identifiers
Aliases	LGALS1, GAL1, GBP, galectin 1
External IDs	OMIM: 150570; MGI: 96777; HomoloGene: 7399; GeneCards: LGALS1; OMA:LGALS1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,679,802 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,814,665 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; decidua; ; Descending thoracic aorta; ; ascending aorta; ; spinal ganglia; ; periodontal fiber; ; body of uterus; ; myometrium; ; left coronary artery; ; trigeminal ganglion;
	Top expressed in
	endothelial cell of lymphatic vessel; ; dermis; ; efferent ductule; ; vas deferens; ; internal carotid artery; ; calvaria; ; condyle; ; ascending aorta; ; external carotid artery; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; lactose binding; signal transducer activity; laminin binding; carbohydrate binding; RNA binding; protein binding;
Cellular component	cytoplasm; extracellular matrix; intracellular anatomical structure; cell surface; extracellular exosome; nucleus; extracellular space; cytosol; endoplasmic reticulum lumen; extracellular region;
Biological process	negative regulation of cell-substrate adhesion; regulation of apoptotic process; negative regulation of neuron projection development; T cell costimulation; cellular response to organic cyclic compound; positive regulation of viral entry into host cell; plasma cell differentiation; positive regulation of erythrocyte aggregation; response to axon injury; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of dendritic cell differentiation; myoblast differentiation; cellular response to glucose stimulus; apoptotic process; signal transduction; response to isolation stress; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	3956
	16852
	ENSG00000100097
	ENSMUSG00000068220
	P09382
	P16045
	NM_002305
	NM_008495
	NP_002296
	NP_032521
	Wikidata
View/Edit Human	View/Edit Mouse

Galectin-1 is a protein that in humans is encoded by the LGALS1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100097 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068220 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gitt MA, Barondes SH (January 1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry. 30 (1): 82–89. doi:10.1021/bi00215a013. PMID 1988031.
^ Gauthier L, Rossi B, Roux F, Termine E, Schiff C (October 2002). "Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering". Proceedings of the National Academy of Sciences of the United States of America. 99 (20): 13014–13019. Bibcode:2002PNAS...9913014G. doi:10.1073/pnas.202323999. PMC 130578. PMID 12271131.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100097 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068220 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1988031-5] Gitt MA, Barondes SH (January 1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry. 30 (1): 82–89. doi:10.1021/bi00215a013. PMID 1988031.

[pmid12271131-6] Gauthier L, Rossi B, Roux F, Termine E, Schiff C (October 2002). "Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering". Proceedings of the National Academy of Sciences of the United States of America. 99 (20): 13014–13019. Bibcode:2002PNAS...9913014G. doi:10.1073/pnas.202323999. PMC 130578. PMID 12271131.

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