Galectin-3

LGALS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A3K, 1KJL, 1KJR, 2NMN, 2NMO, 2NN8, 2XG3, 3AYA, 3AYC, 3AYD, 3AYE, 3T1L, 3T1M, 3ZSJ, 3ZSK, 3ZSL, 3ZSM, 4BLI, 4BLJ, 4BM8, 4JC1, 4JCK, 4LBJ, 4LBK, 4LBL, 4LBM, 4LBN, 4LBO, 4R9A, 4R9B, 4R9C, 4R9D, 4RL7, 4XBN, 5H9R, 5H9P
Identifiers
Aliases	LGALS3, CBP35, GAL3, GALBP, GALIG, L31, LGALS2, MAC2, lectin, galactoside binding soluble 3, galectin 3
External IDs	OMIM: 153619; MGI: 96778; HomoloGene: 37608; GeneCards: LGALS3; OMA:LGALS3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 55,124,110 bp[1] End 55,145,423 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 47,605,208 bp[2] End 47,623,617 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of colon palpebral conjunctiva mucosa of sigmoid colon bronchial epithelial cell nasal epithelium decidua mucosa of ileum jejunal mucosa mucosa of transverse colon amniotic fluid Top expressed in skin of external ear left colon decidua transitional epithelium of urinary bladder calvaria granulocyte gastrula stroma of bone marrow lip skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding chemoattractant activity IgE binding laminin binding carbohydrate binding RNA binding oligosaccharide binding protein phosphatase inhibitor activity protein phosphatase binding Cellular component cytoplasm membrane extracellular matrix plasma membrane immunological synapse mitochondrial inner membrane spliceosomal complex extracellular exosome nucleus extracellular space secretory granule membrane ficolin-1-rich granule membrane galectin complex extracellular region cell surface collagen-containing extracellular matrix Biological process negative regulation of endocytosis cell differentiation regulation of T cell proliferation negative regulation of immunological synapse formation epithelial cell differentiation monocyte chemotaxis immune system process mRNA processing eosinophil chemotaxis negative regulation of extrinsic apoptotic signaling pathway positive regulation of mononuclear cell migration neutrophil chemotaxis negative regulation of T cell receptor signaling pathway mononuclear cell migration positive regulation of calcium ion import macrophage chemotaxis regulation of T cell apoptotic process RNA splicing positive regulation of dendritic cell differentiation regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive chemotaxis innate immune response neutrophil degranulation antimicrobial humoral immune response mediated by antimicrobial peptide regulation of myeloid cell differentiation positive regulation of protein homodimerization activity positive regulation of protein localization to plasma membrane negative regulation of protein tyrosine phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3958 16854 Ensembl ENSG00000131981 ENSMUSG00000050335 UniProt P17931 P16110 RefSeq (mRNA) NM_001177388 NM_002306 NM_001357678 NM_001145953 NM_010705 RefSeq (protein) NP_002297 NP_001344607 n/a Location (UCSC) Chr 14: 55.12 – 55.15 Mb Chr 14: 47.61 – 47.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Galectin-3 is a protein that in humans is encoded by the LGALS3 gene.^[5][6] Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified.^[7][8]

Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides.^{[7][9][10][11]}

Galectin-3 (Gal-3) is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis.

Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21–q22.^[7][12] Galectin-3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface, and extracellular space.^[7][9][10]