Galectin-4

LGALS4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X50, 4YLZ, 4YM0, 4YM1, 4YM2, 4YM3, 5CBL, 5DUW, 4XZP, 5DUX, 5DUU, 5DUV
Identifiers
Aliases	LGALS4, GAL4, L36LBP, galectin 4
External IDs	OMIM: 602518; MGI: 107536; HomoloGene: 21239; GeneCards: LGALS4; OMA:LGALS4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,812,945 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,541,133 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; duodenum; ; gallbladder; ; appendix; ; islet of Langerhans; ; right lobe of liver; ; body of pancreas; ; gastric mucosa; ; body of stomach;
	Top expressed in
	left colon; ; ileum; ; epithelium of small intestine; ; crypt of lieberkuhn of small intestine; ; migratory enteric neural crest cell; ; duodenum; ; intestinal villus; ; Ileal epithelium; ; mucous cell of stomach; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	galactoside binding; carbohydrate binding;
Cellular component	cytosol; plasma membrane; extracellular space; collagen-containing extracellular matrix;
Biological process	cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	3960
	16855
	ENSG00000171747; ENSG00000282992
	ENSMUSG00000053964
	P56470
	Q8K419
	NM_006149
	NM_010706
	NP_006140
	NP_034836
	Wikidata
View/Edit Human	View/Edit Mouse

Galectin-4 is a protein that in humans is encoded by the LGALS4 gene.^[5]^[6]

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS4 is an S-type lectin that is strongly underexpressed in colorectal cancer. The 323-amino acid LGALS4 protein contains two homologous, approximately 150-amino acid carbohydrate recognition domains and all amino acids typically conserved in galectins.^[6]

^ ^a ^b ^c ENSG00000282992 GRCh38: Ensembl release 89: ENSG00000171747, ENSG00000282992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053964 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Barondes SH, Cooper DN, Gitt MA, Leffler H (Sep 1994). "Galectins. Structure and function of a large family of animal lectins". J Biol Chem. 269 (33): 20807–10. doi:10.1016/S0021-9258(17)31891-4. PMID 8063692.
^ ^a ^b "Entrez Gene: LGALS4 lectin, galactoside-binding, soluble, 4 (galectin 4)".

[refGRCh38Ensembl-1] ENSG00000282992 GRCh38: Ensembl release 89: ENSG00000171747, ENSG00000282992 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053964 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8063692-5] Barondes SH, Cooper DN, Gitt MA, Leffler H (Sep 1994). "Galectins. Structure and function of a large family of animal lectins". J Biol Chem. 269 (33): 20807–10. doi:10.1016/S0021-9258(17)31891-4. PMID 8063692.

[entrez-6] "Entrez Gene: LGALS4 lectin, galactoside-binding, soluble, 4 (galectin 4)".

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