Galectin-9

LGALS9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EAK, 2EAL, 2YY1, 2ZHK, 2ZHL, 2ZHM, 2ZHN, 3LSD, 3LSE, 3NV1, 3NV2, 3NV3, 3NV4, 3WLU, 3WV6
Identifiers
Aliases	LGALS9, HUAT, LGALS9A, galectin 9
External IDs	OMIM: 601879; MGI: 109496; HomoloGene: 32078; GeneCards: LGALS9; OMA:LGALS9 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 27,629,798 bp[1] End 27,649,560 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 78,853,800 bp[2] End 78,875,772 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte mucosa of transverse colon rectum gallbladder spleen epithelium of colon lymph node pylorus appendix Top expressed in gastric mucosa mucous cell of stomach epithelium of stomach pyloric antrum seminal vesicula left lobe of liver duodenum crypt of lieberkuhn of small intestine thymus granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function galactose binding signal transducer activity enzyme binding disaccharide binding carbohydrate binding Cellular component intracellular anatomical structure extracellular region extracellular exosome cytoplasm nucleus extracellular space cytosol Biological process negative regulation of interferon-gamma production response to interleukin-1 toll-like receptor 4 signaling pathway maternal process involved in female pregnancy positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell immune system process positive regulation of CD4-positive, alpha-beta T cell proliferation ERK1 and ERK2 cascade female pregnancy positive regulation of viral entry into host cell positive regulation of monocyte chemotactic protein-1 production natural killer cell tolerance induction negative regulation of chemokine production regulation of interleukin-5 production toll-like receptor 2 signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway negative regulation of mast cell degranulation negative regulation of gene expression positive regulation of interleukin-4 production chemotaxis negative regulation of activated T cell proliferation regulation of interleukin-4 production response to lipopolysaccharide positive regulation of gene expression positive regulation of NF-kappaB transcription factor activity positive regulation of dendritic cell apoptotic process positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma positive regulation of I-kappaB kinase/NF-kappaB signaling p38MAPK cascade negative regulation of natural killer cell mediated cytotoxicity positive regulation of transforming growth factor beta production negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of dendritic cell differentiation negative regulation of tumor necrosis factor production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response inflammatory response regulation of p38MAPK cascade mature conventional dendritic cell differentiation positive regulation of dendritic cell chemotaxis positive regulation of activated T cell autonomous cell death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3965 16859 Ensembl ENSG00000168961 ENSMUSG00000001123 UniProt O00182 O08573 RefSeq (mRNA) NM_002308 NM_009587 NM_001330163 NM_001159301 NM_010708 RefSeq (protein) NP_001317092 NP_002299 NP_033665 NP_001152773 NP_034838 Location (UCSC) Chr 17: 27.63 – 27.65 Mb Chr 11: 78.85 – 78.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Galectin-9 was first isolated from mouse embryonic kidney in 1997 as a 36 kDa beta-galactoside lectin protein.^[5] Human galectin-9 is encoded by the LGALS9 gene.^[6][7]