Gap-43 protein

GAP43
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4E53
Identifiers
Aliases	GAP43, B-50, PP46, growth associated protein 43, GAP-43
External IDs	OMIM: 162060; MGI: 95639; HomoloGene: 1545; GeneCards: GAP43; OMA:GAP43 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.31 Start 115,623,510 bp[1] End 115,721,490 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B4|16 28.37 cM Start 42,068,805 bp[2] End 42,161,014 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole Brodmann area 23 right frontal lobe dorsolateral prefrontal cortex superior frontal gyrus orbitofrontal cortex Brodmann area 9 cingulate gyrus anterior cingulate cortex Top expressed in superior cervical ganglion ventromedial nucleus ventral tegmental area lateral hypothalamus lateral septal nucleus anterior amygdaloid area paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus arcuate nucleus nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lysophosphatidic acid binding phosphatidylinositol phosphate binding phosphatidylserine binding calmodulin binding protein binding Cellular component cytoplasm cell projection membrane postsynaptic density growth cone membrane synapse axon cell junction cell periphery filopodium membrane plasma membrane GABA-ergic synapse Biological process regulation of filopodium assembly cell differentiation cell fate commitment tissue regeneration glial cell differentiation nervous system development multicellular organism development protein kinase C-activating G protein-coupled receptor signaling pathway response to wounding regulation of growth axon choice point recognition axon development axon guidance regulation of postsynaptic specialization assembly axon regeneration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2596 14432 Ensembl ENSG00000172020 ENSMUSG00000047261 UniProt P17677 P06837 RefSeq (mRNA) NM_002045 NM_001130064 NM_008083 RefSeq (protein) NP_001123536 NP_002036 NP_032109 Location (UCSC) Chr 3: 115.62 – 115.72 Mb Chr 16: 42.07 – 42.16 Mb PubMed search [3] [4]
Wikidata
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Growth Associated Protein 43 (GAP43) is a protein encoded by the GAP43 gene^[5] in humans.

GAP43 is called a "growth" or "plasticity" protein because it is expressed at high levels in neuronal growth cones during development^[6] and axonal regeneration, and it is phosphorylated after long-term potentiation and after learning.^{[citation needed]}

GAP43 is a crucial component of the axon and presynaptic terminal. Its null mutation leads to death within days after birth, due to axon pathfinding defects.^[7]