Gary Ruvkun | |
|---|---|
 Ruvkun in 2014 | |
| Born | March 26, 1952[1] Berkeley, California, U.S.[2] |
| Alma mater | University of California, Berkeley (BA) Harvard University (PhD) |
| Awards | |
| Scientific career | |
| Institutions | University of California, Berkeley Harvard University Massachusetts Institute of Technology Massachusetts General Hospital |
| Thesis | The molecular genetic analysis of symbiotic nitrogen fixation (NIF) genes from rhizobium meliloti (1982) |
| Doctoral advisor | Frederick Ausubel |
| Website | ruvkun |
Gary Bruce Ruvkun (born March 26, 1952) is an American molecular biologist and Nobel laureate at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston.[3]
Ruvkun discovered the mechanism by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7, and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism.
He was elected a Member of the American Philosophical Society in 2019. Ruvkun was awarded the 2024 Nobel Prize in Physiology or Medicine for the discovery of microRNA and its role in post-transcriptional gene regulation.[4]
- ^ "Who are Victor Ambros and Gary Ruvkun, winners of 2024 Nobel Prize in Medicine?". Hindustan Times. Archived from the original on October 7, 2024. Retrieved October 7, 2024.
- ^ Who's Who in America 66th edition. Vol 2: M–Z. Marquis Who's Who, Berkeley Heights 2011, p. 3862
- ^ Nair, P. (2011). "Profile of Gary Ruvkun". Proceedings of the National Academy of Sciences. 108 (37): 15043–5. Bibcode:2011PNAS..10815043N. doi:10.1073/pnas.1111960108. PMC 3174634. PMID 21844349.
- ^ "Press release: The Nobel Prize in Physiology or Medicine 2024". NobelPrize.org. Archived from the original on October 8, 2024. Retrieved October 7, 2024.