Genome Project-Write

Since the Human Genome Project first sequenced the human genome from 1987 to 2004 at a cost of US$3 billion, costs have fallen precipitously, outpacing even Moore's law, and were ≈US$1,000 in 2015. More widely available genome sequencing has led to more data on variants of uncertain significance.

The Genome Project - Write (also known as GP-Write) is a large-scale collaborative research project (an extension of Genome Projects, aimed at reading genomes since 1984) that focuses on the development of technologies for the synthesis and testing of genomes of many different species of microbes, plants, and animals, including the human genome in a sub-project known as Human Genome Project-Write (HGP-Write).[1][2][3][4][5][6] Formally announced on 2 June 2016, the project leverages two decades of work on synthetic biology and artificial gene synthesis.

The newly created GP-Write project will be managed by the Center of Excellence for Engineering Biology,[7] an American nonprofit organization. Researchers expect that the ability to artificially synthesize large portions of many genomes will result in many scientific and medical advances.[1][2][3][4][5][6]

  1. ^ a b Pollack, Andrew (2 June 2016). "Scientists Announce HGP-Write, Project to Synthesize the Human Genome". The New York Times. Retrieved 2 June 2016.
  2. ^ a b Boeke, JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L; et al. (2 June 2016). "The Genome Project–Write". Science. 353 (6295): 126–127. Bibcode:2016Sci...353..126B. doi:10.1126/science.aaf6850. PMID 27256881. S2CID 206649424. Retrieved 2 June 2016.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ a b Callaway, Ewen (2 June 2016). "Plan to Synthesize Human Genome Triggers a Mixed Response". Scientific American. Retrieved 2 June 2016.
  4. ^ a b Regalado, Antonio (2 June 2016). "Plan to Fabricate a Genome Raises Questions on Designer Humans". MIT Technology Review. Retrieved 2 June 2016.
  5. ^ a b Akst, Jef (2 June 2016). ""Human Genome Project-Write" Unveiled". The Scientist. Retrieved 2 June 2016.
  6. ^ a b Opal, Puneet; Kini, Ameet (3 June 2016). "The Brave New World of the Synthetic Human Genome". Time. Retrieved 12 June 2016.
  7. ^ "Center of Excellence for Engineering Biology". Retrieved 2 March 2017.