George Cooke may refer to:
- Sir George Cooke, 3rd Baronet (1662–1732), British MP for Aldborough, 1698–1700
- George Cooke (died 1768), British MP for Middlesex and Tregony
- George Cooke (Australian politician) (1869–1938), member of the South Australian House of Assembly for Barossa
- George Cooke (barrister) (1645–1740), subject of a statue by Sir Henry Cheere, 1st Baronet
- George Cooke (British Army officer) (1768–1837), Major-General commanding the British 1st Division at the Battle of Waterloo
- George Cooke (cricketer) (1826–1862), English cricketer
- George Cooke (Deputy Governor of Bombay), Deputy Governor of Bombay, 1689–1690
- George Cooke (engraver) (1781–1834), British engraver
- George Cooke (footballer) (1899–1977), English footballer
- George Cooke (Massachusetts politician) (died 1652), Massachusetts colonial politician
- George Cooke (painter) (1793–1849), American painter
- George Cooke (rower) (1906–1941), New Zealand Olympic rower
- George A. Cooke (1869–1938), chief justice of the Illinois Supreme Court, 1913–1914
- George Albert Cooke (1865–1939), Anglican clergyman and academic
- George Atwell Cooke, Ontario lawyer and political figure
- George Edwin Cooke (1883–1969), American Olympic football (soccer) player
- George Frederick Cooke (1756–1812), English actor
- George Leigh Cooke (c. 1779–1853), mathematician and priest
- George W. Cooke (1916–1992), British chemist
- George Willis Cooke (1848–1923), Unitarian minister, writer, editor, and lecturer
- George Wingrove Cooke (1814–1865), British lawyer and historian