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George Mercer Brooke (October 16, 1785 – March 9, 1851) was a brevet major general in the U.S. Army. While a colonel, Brooke was ordered in 1823, along with James Gadsden, to establish a military presence in the vicinity of Tampa Bay, in the newly acquired Florida Territory.
Objectives included containing the Seminole Indians and curtailing illegal activities along the Gulf Coast.