Giant condyloma acuminatum

Giant condyloma acuminatum
Other namesGiant condyloma of Buschke–Löwenstein tumor
Man, aged 63, with a massive cauliflower-like penile mass with several urinary fistulae making the penile shaft indistinguishable.
SpecialtyInfectious diseases Edit this on Wikidata

Giant condyloma acuminatum (also known as a Buschke–Löwenstein tumor[1]) is a rare cutaneous condition characterized by an aggressive, wart-like growth that is a verrucous carcinoma.[2]: 409  It is attributed to human papillomavirus.[3]

Due to their size, these tumors can be locally invasive and destructive. Owing to their impressive growth patterns, Buschke-Löwenstein tumors displace and destroy adjacent structures from compression.[4] In general these masses are benign, but the potential for malignant transformation to squamous cell carcinoma exists in the long term, as does the rare risk for metastasis.[5][6][7][8] Buschke-Löwensteoin tumors are frequently associated with HPV subtypes 6 and 11.[4]

Treatment involves surgical resection and possible chemoradiotherapy.[6][8][7] Although penile sparing is the goal, total penectomy may be required. They have high recurrence rates; therefore, close follow-up is crucial.[4]

  1. ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  3. ^ "Condyloma Acuminata". Retrieved 2010-09-22.
  4. ^ a b c Pettaway CA, Crook JM, Pagliaro LC. Tumors of the penis. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, eds. Campbell-Walsh Urology. 11th ed. Philadelphia, PA: Elsevier; 2016: ch 37.
  5. ^ Safi F, Bekdache O, Al-Salam S, Alashari M, Mazen T. Giant condyloma acuminatum of Buschke–Lowenstein tumour: disease development between 2000 and 2010. Surg Pract. 2014 Feb;2014:18(1):27-36. Available at doi:10.1111/1744-1633.12047. Accessed April 15, 2020.
  6. ^ a b Kim HG, Kesey JE, Griswold JA. Giant anorectal condyloma acuminatum of Buschke-Löwenstein presents difficult management decisions. J Surg Case Rep. 2018 Apr 3;2018(4):rjy058. PMID 29644039
  7. ^ a b Venter F, Heidari A, Viehweg M, Rivera M, Natarajan P, Cobos E. Giant condylomata acuminata of Buschke-Lowenstein associated with paraneoplastic hypercalcemia. J Investig Med High Impact Case Rep. 2018 Feb 15;6:2324709618758348. PMID 29479542
  8. ^ a b Papapanagiotou IK, Migklis K, Ioannidou G, et al. Giant condyloma acuminatum-malignant transformation. Clin Case Rep. 2017 Feb 23;5(4):537-8. PMID 28396786