| Glucose oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of glucose oxidase dimer (dark and light blue) complexed with FAD (salmon) and glycans (aquamarine) from Penicillium amagasakiense.[1] | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.3.4 | ||||||||
| CAS no. | 9001-37-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
-alpha-D-Glucose.svg)
| |
| Names | |
|---|---|
| Other names
Oxidase, glucose
| |
| Identifiers | |
| ChemSpider |
|
| ECHA InfoCard | 100.029.625 |
| EC Number |
|
| E number | E1102 (additional chemicals) |
| KEGG | |
| UNII | |
CompTox Dashboard (EPA)
|
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| Properties | |
| (C6H10O5)n | |
| Molar mass | variable |
| Appearance | white or yellow powder |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
The glucose oxidase enzyme (GOx or GOD) also known as notatin (EC number 1.1.3.4) is an oxidoreductase that catalyses the oxidation of glucose to hydrogen peroxide and D-glucono-δ-lactone. This enzyme is produced by certain species of fungi and insects and displays antibacterial activity when oxygen and glucose are present.[2]
Glucose oxidase is widely used for the determination of free glucose in body fluids (medical testing), in vegetal raw material, and in the food industry. It also has many applications in biotechnologies, typically enzyme assays for biochemistry including biosensors in nanotechnologies.[3][4] It was first isolated by Detlev Müller in 1928 from Aspergillus niger.[5]
- ^ PDB: 1gpe; Goodsell D (May 2006). "Molecule of the Month: Glucose Oxidase". RCSB Protein Data Bank. doi:10.2210/rcsb_pdb/mom_2006_5.
- ^ Wong CM, Wong KH, Chen XD (Apr 2008). "Glucose oxidase: natural occurrence, function, properties and industrial applications". Applied Microbiology and Biotechnology. 78 (6): 927–938. doi:10.1007/s00253-008-1407-4. PMID 18330562. S2CID 2246466.
- ^ "Glucose Oxidase Technical sheet" (PDF). Interchim.[permanent dead link]
- ^ Ghoshdastider U, Xu R, Trzaskowski B, Mlynarczyk K, Miszta P, Viswanathan S, Renugopalakrishnan V, Filipek S (2015). "Molecular Effects of Encapsulation of Glucose Oxidase Dimer by Graphene". RSC Advances. 5 (18): 13570–8. Bibcode:2015RSCAd...513570G. doi:10.1039/C4RA16852F.
- ^ "Detlev Müller discovers glucose oxidase". Tacomed.com. Archived from the original on 18 April 2018. Retrieved 13 June 2017.
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