Glucuronosyltransferase

Glucuronosyltransferase
Glucuronosyltransferase monomer, Xanthomonas campestris
Identifiers
EC no.2.4.1.17
CAS no.9030-08-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
UDP-glucuronosyl and UDP-glucosyl transferase
Structure of TDP-vancosaminyltransferase GtfD as a complex with TDP and the natural substrate, desvancosaminyl vancomycin.[1]
Identifiers
SymbolUDPGT
PfamPF00201
InterProIPR002213
PROSITEPDOC00359
SCOP21rrv / SCOPe / SUPFAM
Membranome476
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase (EC 2.4.1.17) that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction.[2][3]

Alternative names:

  • glucuronyltransferase
  • UDP-glucuronyl transferase
  • UDP-GT
  1. ^ Mulichak AM, Lu W, Losey HC, Walsh CT, Garavito RM (May 2004). "Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands". Biochemistry. 43 (18): 5170–5180. doi:10.1021/bi036130c. PMID 15122882.
  2. ^ King C, Rios G, Green M, Tephly T (2000). "UDP-glucuronosyltransferases". Curr Drug Metab. 1 (2): 143–161. doi:10.2174/1389200003339171. PMID 11465080.
  3. ^ "UDP-glucuronosyltransferase 1-1". Drugbank. Retrieved 21 November 2019.