| Formiminotransferase domain, N-terminal subdomain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Formiminotransferase domain of formiminotransferase-cyclodeaminase, homodimer, Sus scrofa | |||||||||
| Identifiers | |||||||||
| Symbol | FTCD_N | ||||||||
| Pfam | PF07837 | ||||||||
| InterPro | IPR012886 | ||||||||
| SCOP2 | 1qd1 / SCOPe / SUPFAM | ||||||||
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| Formiminotransferase domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 the crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase. | |||||||||
| Identifiers | |||||||||
| Symbol | FTCD | ||||||||
| Pfam | PF02971 | ||||||||
| InterPro | IPR013802 | ||||||||
| SCOP2 | 1qd1 / SCOPe / SUPFAM | ||||||||
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Glutamate formimidoyltransferase is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism. It catalyses two reactions:
- 5-formimidoyltetrahydrofolate + L-glutamate <=> tetrahydrofolate + N-formimidoyl-L-glutamate
- 5-formyltetrahydrofolate + L-glutamate <=> tetrahydrofolate + N-formyl-L-glutamate
It is classified under EC 2.1.2.5 and in mammals is found as part of a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase activity.[1]
- ^ MacKenzie RE, Aldridge M, Paquin J (10 October 1980). "The bifunctional enzyme formiminotransferase-cyclodeaminase is a tetramer of dimers". J. Biol. Chem. 255 (19): 9474–8. doi:10.1016/S0021-9258(19)70586-9. PMID 7410436.[permanent dead link]