Goldwasser is a Jewish surname. Notable people with the surname include:
- Benjamin Goldwasser, member of MGMT
- Eugene Goldwasser, biochemist
- Ehud Goldwasser, an Israeli soldier
- I. Edwin Goldwasser, American teacher, philanthropist, and businessman
- Joseph Goldwasser, Polish-born American businessman
- Ned Goldwasser, American physicist
- Orly Goldwasser, professor of Egyptology
- Robin Goldwasser, an American singer and playwright
- Shafi Goldwasser, Turing Award-winning professor at MIT